An exome array study of the plasma metabolome

Eugene P. Rhee (), Qiong Yang, Bing Yu, Xuan Liu, Susan Cheng, Amy Deik, Kerry A. Pierce, Kevin Bullock, Jennifer E. Ho, Daniel Levy, Jose C. Florez, Sek Kathiresan, Martin G. Larson, Ramachandran S. Vasan, Clary B. Clish, Thomas J. Wang, Eric Boerwinkle, Christopher J. O’Donnell and Robert E. Gerszten ()
Additional contact information
Eugene P. Rhee: Massachusetts General Hospital
Qiong Yang: Boston University School of Public Health
Bing Yu: Human Genetics Center, University of Texas Health Science Center at Houston
Xuan Liu: Boston University School of Public Health
Susan Cheng: National Heart, Lung and Blood Institute’s Framingham Heart Study
Amy Deik: Metabolite Profiling, Broad Institute of MIT and Harvard
Kerry A. Pierce: Metabolite Profiling, Broad Institute of MIT and Harvard
Kevin Bullock: Metabolite Profiling, Broad Institute of MIT and Harvard
Jennifer E. Ho: Massachusetts General Hospital
Daniel Levy: National Heart, Lung and Blood Institute’s Framingham Heart Study
Jose C. Florez: Diabetes Research Center, Massachusetts General Hospital
Sek Kathiresan: Massachusetts General Hospital
Martin G. Larson: Boston University School of Public Health
Ramachandran S. Vasan: National Heart, Lung and Blood Institute’s Framingham Heart Study
Clary B. Clish: Metabolite Profiling, Broad Institute of MIT and Harvard
Thomas J. Wang: Vanderbilt University Medical Center
Eric Boerwinkle: Human Genetics Center, University of Texas Health Science Center at Houston
Christopher J. O’Donnell: National Heart, Lung and Blood Institute’s Framingham Heart Study
Robert E. Gerszten: Beth Israel Deaconess Medical Center

Nature Communications, 2016, vol. 7, issue 1, 1-7

Abstract: Abstract The study of rare variants may enhance our understanding of the genetic determinants of the metabolome. Here, we analyze the association between 217 plasma metabolites and exome variants on the Illumina HumanExome Beadchip in 2,076 participants in the Framingham Heart Study, with replication in 1,528 participants of the Atherosclerosis Risk in Communities Study. We identify an association between GMPS and xanthosine using single variant analysis and associations between HAL and histidine, PAH and phenylalanine, and UPB1 and ureidopropionate using gene-based tests (P

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.nature.com/articles/ncomms12360 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12360

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms12360

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().