Total synthesis of teixobactin

Kang Jin, Iek Hou Sam, Kathy Hiu Laam Po, Du’an Lin, Ebrahim H. Ghazvini Zadeh, Sheng Chen (), Yu Yuan () and Xuechen Li ()
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Kang Jin: State Key Lab of Synthetic Chemistry, The University of Hong Kong
Iek Hou Sam: State Key Lab of Synthetic Chemistry, The University of Hong Kong
Kathy Hiu Laam Po: The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Du’an Lin: State Key Lab of Synthetic Chemistry, The University of Hong Kong
Ebrahim H. Ghazvini Zadeh: University of Central Florida
Sheng Chen: The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
Yu Yuan: University of Central Florida
Xuechen Li: State Key Lab of Synthetic Chemistry, The University of Hong Kong

Nature Communications, 2016, vol. 7, issue 1, 1-6

Abstract: Abstract To cope with the global bacterial multidrug resistance, scientific communities have devoted significant efforts to develop novel antibiotics, particularly those with new modes of actions. Teixobactin, recently isolated from uncultured bacteria, is considered as a promising first-in-class drug candidate for clinical development. Herein, we report its total synthesis by a highly convergent Ser ligation approach and this strategy allows us to prepare several analogues of the natural product.

Date: 2016
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DOI: 10.1038/ncomms12394

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