Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

Kouya Shiraishi, Yukinori Okada, Atsushi Takahashi, Yoichiro Kamatani, Yukihide Momozawa, Kyota Ashikawa, Hideo Kunitoh, Shingo Matsumoto, Atsushi Takano, Kimihiro Shimizu, Akiteru Goto, Koji Tsuta, Shun-ichi Watanabe, Yuichiro Ohe, Yukio Watanabe, Yasushi Goto, Hiroshi Nokihara, Koh Furuta, Akihiko Yoshida, Koichi Goto, Tomoyuki Hishida, Masahiro Tsuboi, Katsuya Tsuchihara, Yohei Miyagi, Haruhiko Nakayama, Tomoyuki Yokose, Kazumi Tanaka, Toshiteru Nagashima, Yoichi Ohtaki, Daichi Maeda, Kazuhiro Imai, Yoshihiro Minamiya, Hiromi Sakamoto, Akira Saito, Yoko Shimada, Kuniko Sunami, Motonobu Saito, Johji Inazawa, Yusuke Nakamura, Teruhiko Yoshida, Jun Yokota, Fumihiko Matsuda, Keitaro Matsuo, Yataro Daigo, Michiaki Kubo and Takashi Kohno ()
Additional contact information
Kouya Shiraishi: National Cancer Center Research Institute
Yukinori Okada: Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
Atsushi Takahashi: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
Yoichiro Kamatani: Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
Yukihide Momozawa: Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN
Kyota Ashikawa: Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN
Hideo Kunitoh: Japanese Red Cross Medical Center
Shingo Matsumoto: Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center Research Institute
Atsushi Takano: Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo
Kimihiro Shimizu: Gunma University Hospital
Akiteru Goto: Graduate School of Medicine, Akita University
Koji Tsuta: National Cancer Center Hospital
Shun-ichi Watanabe: National Cancer Centre Hospital
Yuichiro Ohe: National Cancer Center Hospital
Yukio Watanabe: National Cancer Centre Hospital
Yasushi Goto: National Cancer Center Hospital
Hiroshi Nokihara: National Cancer Center Hospital
Koh Furuta: National Cancer Center Hospital
Akihiko Yoshida: National Cancer Center Hospital
Koichi Goto: National Cancer Center Hospital East
Tomoyuki Hishida: National Cancer Center Hospital East
Masahiro Tsuboi: National Cancer Center Hospital East
Katsuya Tsuchihara: Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center Research Institute
Yohei Miyagi: Kanagawa Cancer Center Research Institute
Haruhiko Nakayama: Kanagawa Cancer Center
Tomoyuki Yokose: Kanagawa Cancer Center
Kazumi Tanaka: Gunma University Hospital
Toshiteru Nagashima: Gunma University Hospital
Yoichi Ohtaki: Gunma University Hospital
Daichi Maeda: Graduate School of Medicine, Akita University
Kazuhiro Imai: Graduate School of Medicine, Akita University
Yoshihiro Minamiya: Graduate School of Medicine, Akita University
Hiromi Sakamoto: National Cancer Center Research Institute
Akira Saito: StaGen Co., Ltd.
Yoko Shimada: National Cancer Center Research Institute
Kuniko Sunami: National Cancer Center Research Institute
Motonobu Saito: National Cancer Center Research Institute
Johji Inazawa: Medical Research Institute, Tokyo Medical and Dental University
Yusuke Nakamura: Center for Personalized Therapeutics, The University of Chicago
Teruhiko Yoshida: National Cancer Center Research Institute
Jun Yokota: Genomics and Epigenomics of Cancer Prediction Program, Institute of Predictive and Personalized Medicine of Cancer (IMPPC)
Fumihiko Matsuda: Center for Genomic Medicine, Graduate School of Medicine, Kyoto University
Keitaro Matsuo: Aichi Cancer Center Research Institute
Yataro Daigo: Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo
Michiaki Kubo: Laboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN
Takashi Kohno: National Cancer Center Research Institute

Nature Communications, 2016, vol. 7, issue 1, 1-7

Abstract: Abstract Lung adenocarcinoma driven by somatic EGFR mutations is more prevalent in East Asians (30–50%) than in European/Americans (10–20%). Here we investigate genetic factors underlying the risk of this disease by conducting a genome-wide association study, followed by two validation studies, in 3,173 Japanese patients with EGFR mutation-positive lung adenocarcinoma and 15,158 controls. Four loci, 5p15.33 (TERT), 6p21.3 (BTNL2), 3q28 (TP63) and 17q24.2 (BPTF), previously shown to be strongly associated with overall lung adenocarcinoma risk in East Asians, were re-discovered as loci associated with a higher susceptibility to EGFR mutation-positive lung adenocarcinoma. In addition, two additional loci, HLA class II at 6p21.32 (rs2179920; P =5.1 × 10−17, per-allele OR=1.36) and 6p21.1 (FOXP4) (rs2495239; P=3.9 × 10−9, per-allele OR=1.19) were newly identified as loci associated with EGFR mutation-positive lung adenocarcinoma. This study indicates that multiple genetic factors underlie the risk of lung adenocarcinomas with EGFR mutations.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms12451 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12451

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms12451

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().