Subcompartmentalization by cross-membranes during early growth of Streptomyces hyphae

Paula Yagüe (), Joost Willemse, Roman I. Koning, Beatriz Rioseras, María T. López-García, Nathaly Gonzalez-Quiñonez, Carmen Lopez-Iglesias, Pavel V. Shliaha, Adelina Rogowska-Wrzesinska, Abraham J. Koster, Ole N. Jensen, Gilles P. van Wezel and Ángel Manteca ()
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Paula Yagüe: Área de Microbiología, Facultad de Medicina, Universidad de Oviedo
Joost Willemse: Molecular Biotechnology, Institute of Biology, Leiden University
Roman I. Koning: Leiden University Medical Centre
Beatriz Rioseras: Área de Microbiología, Facultad de Medicina, Universidad de Oviedo
María T. López-García: Área de Microbiología, Facultad de Medicina, Universidad de Oviedo
Nathaly Gonzalez-Quiñonez: Área de Microbiología, Facultad de Medicina, Universidad de Oviedo
Carmen Lopez-Iglesias: Crio-Microscòpia Electrònica. Centres Científics i Tecnològics, Universitat de Barcelona
Pavel V. Shliaha: University of Southern Denmark
Adelina Rogowska-Wrzesinska: University of Southern Denmark
Abraham J. Koster: Leiden University Medical Centre
Ole N. Jensen: University of Southern Denmark
Gilles P. van Wezel: Molecular Biotechnology, Institute of Biology, Leiden University
Ángel Manteca: Área de Microbiología, Facultad de Medicina, Universidad de Oviedo

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract Bacteria of the genus Streptomyces are a model system for bacterial multicellularity. Their mycelial life style involves the formation of long multinucleated hyphae during vegetative growth, with occasional cross-walls separating long compartments. Reproduction occurs by specialized aerial hyphae, which differentiate into chains of uninucleoid spores. While the tubulin-like FtsZ protein is required for the formation of all peptidoglycan-based septa in Streptomyces, canonical divisome-dependent cell division only occurs during sporulation. Here we report extensive subcompartmentalization in young vegetative hyphae of Streptomyces coelicolor, whereby 1 μm compartments are formed by nucleic acid stain-impermeable barriers. These barriers possess the permeability properties of membranes and at least some of them are cross-membranes without detectable peptidoglycan. Z-ladders form during the early growth, but cross-membrane formation does not depend on FtsZ. Thus, a new level of hyphal organization is presented involving unprecedented high-frequency compartmentalization, which changes the old dogma that Streptomyces vegetative hyphae have scarce compartmentalization.

Date: 2016
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DOI: 10.1038/ncomms12467

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