Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma

Harvind S. Chahal, Wenting Wu, Katherine J. Ransohoff, Lingyao Yang, Haley Hedlin, Manisha Desai, Yuan Lin, Hong-Ji Dai, Abrar A. Qureshi, Wen-Qing Li, Peter Kraft, David A. Hinds, Jean Y. Tang, Jiali Han () and Kavita Y. Sarin ()
Additional contact information
Harvind S. Chahal: Stanford University School of Medicine
Wenting Wu: Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Katherine J. Ransohoff: Stanford University School of Medicine
Lingyao Yang: Stanford University School of Medicine
Haley Hedlin: Stanford University School of Medicine
Manisha Desai: Stanford University School of Medicine
Yuan Lin: Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Hong-Ji Dai: Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Abrar A. Qureshi: Warren Alpert Medical School, Brown University
Wen-Qing Li: Warren Alpert Medical School, Brown University
Peter Kraft: Harvard T.H. Chan School of Public Health
David A. Hinds: 23andMe Inc.
Jean Y. Tang: Stanford University School of Medicine
Jiali Han: Richard M. Fairbanks School of Public Health, Melvin & Bren Simon Cancer Center, Indiana University
Kavita Y. Sarin: Stanford University School of Medicine

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct genetic loci and BCC risk. Here, we report the results of a two-stage genome-wide association study of BCC, totalling 17,187 cases and 287,054 controls. We confirm 17 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P

Date: 2016
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DOI: 10.1038/ncomms12510

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