Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates

Vida Chitsazzadeh, Cristian Coarfa, Jennifer A. Drummond, Tri Nguyen, Aaron Joseph, Suneel Chilukuri, Elizabeth Charpiot, Charles H. Adelmann, Grace Ching, Tran N. Nguyen, Courtney Nicholas, Valencia D. Thomas, Michael Migden, Deborah MacFarlane, Erika Thompson, Jianjun Shen, Yoko Takata, Kayla McNiece, Maxim A. Polansky, Hussein A. Abbas, Kimal Rajapakshe, Adam Gower, Avrum Spira, Kyle R. Covington, Weimin Xiao, Preethi Gunaratne, Curtis Pickering, Mitchell Frederick, Jeffrey N. Myers, Li Shen, Hui Yao, Xiaoping Su, Ronald P. Rapini, David A. Wheeler, Ernest T. Hawk, Elsa R. Flores and Kenneth Y. Tsai ()
Additional contact information
Vida Chitsazzadeh: University of Texas MD Anderson Cancer Center Houston
Cristian Coarfa: Baylor College of Medicine
Jennifer A. Drummond: Human Genome Sequencing Center, Baylor College of Medicine
Tri Nguyen: Northwest Diagnostic Clinic
Aaron Joseph: Skin and Laser Surgery Associates
Suneel Chilukuri: Bellaire Dermatology
Elizabeth Charpiot: Bellaire Dermatology
Charles H. Adelmann: University of Texas MD Anderson Cancer Center Houston
Grace Ching: University of Texas MD Anderson Cancer Center Houston
Tran N. Nguyen: University of Texas MD Anderson Cancer Center Houston
Courtney Nicholas: University of Texas MD Anderson Cancer Center Houston
Valencia D. Thomas: University of Texas MD Anderson Cancer Center Houston
Michael Migden: University of Texas MD Anderson Cancer Center Houston
Deborah MacFarlane: University of Texas MD Anderson Cancer Center Houston
Erika Thompson: Sequencing and Microarray Facility, University of Texas MD Anderson Cancer Center Houston,
Jianjun Shen: Next Generation Sequencing Facility, Smithville, University of Texas MD Anderson Cancer Center Houston,
Yoko Takata: Next Generation Sequencing Facility, Smithville, University of Texas MD Anderson Cancer Center Houston,
Kayla McNiece: University of Texas Medical School at Houston
Maxim A. Polansky: University of Texas Medical School at Houston
Hussein A. Abbas: University of Texas MD Anderson Cancer Center Houston
Kimal Rajapakshe: Baylor College of Medicine
Adam Gower: Boston University School of Medicine
Avrum Spira: Boston University School of Medicine
Kyle R. Covington: Baylor College of Medicine
Weimin Xiao: Department of Biology and Biochemistry University of Houston
Preethi Gunaratne: Department of Biology and Biochemistry University of Houston
Curtis Pickering: University of Texas MD Anderson Cancer Center Houston
Mitchell Frederick: University of Texas MD Anderson Cancer Center Houston
Jeffrey N. Myers: University of Texas MD Anderson Cancer Center Houston
Li Shen: University of Texas MD Anderson Cancer Center Houston
Hui Yao: University of Texas MD Anderson Cancer Center Houston
Xiaoping Su: University of Texas MD Anderson Cancer Center Houston
Ronald P. Rapini: University of Texas MD Anderson Cancer Center Houston
David A. Wheeler: Baylor College of Medicine
Ernest T. Hawk: University of Texas MD Anderson Cancer Center Houston
Elsa R. Flores: University of Texas MD Anderson Cancer Center Houston
Kenneth Y. Tsai: University of Texas MD Anderson Cancer Center Houston

Nature Communications, 2016, vol. 7, issue 1, 1-17

Abstract: Abstract Cutaneous squamous cell carcinoma (cuSCC) comprises 15–20% of all skin cancers, accounting for over 700,000 cases in USA annually. Most cuSCC arise in association with a distinct precancerous lesion, the actinic keratosis (AK). To identify potential targets for molecularly targeted chemoprevention, here we perform integrated cross-species genomic analysis of cuSCC development through the preneoplastic AK stage using matched human samples and a solar ultraviolet radiation-driven Hairless mouse model. We identify the major transcriptional drivers of this progression sequence, showing that the key genomic changes in cuSCC development occur in the normal skin to AK transition. Our data validate the use of this ultraviolet radiation-driven mouse cuSCC model for cross-species analysis and demonstrate that cuSCC bears deep molecular similarities to multiple carcinogen-driven SCCs from diverse sites, suggesting that cuSCC may serve as an effective, accessible model for multiple SCC types and that common treatment and prevention strategies may be feasible.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12601

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DOI: 10.1038/ncomms12601

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