Optogenetically enhanced pituitary corticotroph cell activity post-stress onset causes rapid organizing effects on behaviour

Rodrigo J. De Marco (), Theresa Thiemann, Antonia H. Groneberg, Ulrich Herget and Soojin Ryu ()
Additional contact information
Rodrigo J. De Marco: Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research
Theresa Thiemann: Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research
Antonia H. Groneberg: Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research
Ulrich Herget: Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research
Soojin Ryu: Developmental Genetics of the Nervous System, Max Planck Institute for Medical Research

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract The anterior pituitary is the major link between nervous and hormonal systems, which allow the brain to generate adequate and flexible behaviour. Here, we address its role in mediating behavioural adjustments that aid in coping with acutely threatening environments. For this we combine optogenetic manipulation of pituitary corticotroph cells in larval zebrafish with newly developed assays for measuring goal-directed actions in very short timescales. Our results reveal modulatory actions of corticotroph cell activity on locomotion, avoidance behaviours and stimulus responsiveness directly after the onset of stress. Altogether, the findings uncover the significance of endocrine pituitary cells for rapidly optimizing behaviour in local antagonistic environments.

Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms12620 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12620

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms12620

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().