A strategy to discover new organizers identifies a putative heart organizer

Claire Anderson, Mohsin A. F. Khan, Frances Wong, Tatiana Solovieva, Nidia M. M. Oliveira, Richard A. Baldock, Cheryll Tickle, Dave W. Burt and Claudio D. Stern ()
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Claire Anderson: University College London
Mohsin A. F. Khan: University College London
Frances Wong: The Roslin Institute, University of Edinburgh, Easter Bush
Tatiana Solovieva: University College London
Nidia M. M. Oliveira: University College London
Richard A. Baldock: Biomedical Systems Analysis Section, MRC Human Genetics Unit, IGMM, University of Edinburgh
Cheryll Tickle: University of Bath
Dave W. Burt: The Roslin Institute, University of Edinburgh, Easter Bush
Claudio D. Stern: University College London

Nature Communications, 2016, vol. 7, issue 1, 1-9

Abstract: Abstract Organizers are regions of the embryo that can both induce new fates and impart pattern on other regions. So far, surprisingly few organizers have been discovered, considering the number of patterned tissue types generated during development. This may be because their discovery has relied on transplantation and ablation experiments. Here we describe a new approach, using chick embryos, to discover organizers based on a common gene expression signature, and use it to uncover the anterior intestinal portal (AIP) endoderm as a putative heart organizer. We show that the AIP can induce cardiac identity from non-cardiac mesoderm and that it can pattern this by specifying ventricular and suppressing atrial regional identity. We also uncover some of the signals responsible. The method holds promise as a tool to discover other novel organizers acting during development.

Date: 2016
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DOI: 10.1038/ncomms12656

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