The electrophotonic silicon biosensor

José Juan-Colás (), Alison Parkin (), Katherine E. Dunn, Mark G. Scullion, Thomas F. Krauss and Steven D. Johnson
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José Juan-Colás: University of York
Alison Parkin: University of York
Katherine E. Dunn: University of York
Mark G. Scullion: University of York
Thomas F. Krauss: University of York
Steven D. Johnson: University of York

Nature Communications, 2016, vol. 7, issue 1, 1-7

Abstract: Abstract The emergence of personalized and stratified medicine requires label-free, low-cost diagnostic technology capable of monitoring multiple disease biomarkers in parallel. Silicon photonic biosensors combine high-sensitivity analysis with scalable, low-cost manufacturing, but they tend to measure only a single biomarker and provide no information about their (bio)chemical activity. Here we introduce an electrochemical silicon photonic sensor capable of highly sensitive and multiparameter profiling of biomarkers. Our electrophotonic technology consists of microring resonators optimally n-doped to support high Q resonances alongside electrochemical processes in situ. The inclusion of electrochemical control enables site-selective immobilization of different biomolecules on individual microrings within a sensor array. The combination of photonic and electrochemical characterization also provides additional quantitative information and unique insight into chemical reactivity that is unavailable with photonic detection alone. By exploiting both the photonic and the electrical properties of silicon, the sensor opens new modalities for sensing on the microscale.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms12769

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DOI: 10.1038/ncomms12769

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