A dendritic disinhibitory circuit mechanism for pathway-specific gating

Guangyu Robert Yang, John D. Murray and Xiao-Jing Wang ()
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Guangyu Robert Yang: Center for Neural Science, New York University
John D. Murray: Center for Neural Science, New York University
Xiao-Jing Wang: Center for Neural Science, New York University

Nature Communications, 2016, vol. 7, issue 1, 1-14

Abstract: Abstract While reading a book in a noisy café, how does your brain ‘gate in’ visual information while filtering out auditory stimuli? Here we propose a mechanism for such flexible routing of information flow in a complex brain network (pathway-specific gating), tested using a network model of pyramidal neurons and three classes of interneurons with connection probabilities constrained by data. We find that if inputs from different pathways cluster on a pyramidal neuron dendrite, a pathway can be gated-on by a disinhibitory circuit motif. The branch-specific disinhibition can be achieved despite dense interneuronal connectivity, even with random connections. Moreover, clustering of input pathways on dendrites can naturally emerge through synaptic plasticity regulated by dendritic inhibition. This gating mechanism in a neural circuit is further demonstrated by performing a context-dependent decision-making task. The model suggests that cognitive flexibility engages top-down signalling of behavioural rule or context that targets specific classes of inhibitory neurons.

Date: 2016
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DOI: 10.1038/ncomms12815

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