A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques

Sujin Lee, Minh Trang Nguyen, Michael G. Currier, Joe B. Jenkins, Elizabeth A. Strobert, Adriana E. Kajon, Ranjna Madan-Lala, Yury A. Bochkov, James E. Gern, Krishnendu Roy, Xiaoyan Lu, Dean D. Erdman, Paul Spearman and Martin L. Moore ()
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Sujin Lee: Emory University
Minh Trang Nguyen: Emory University
Michael G. Currier: Emory University
Joe B. Jenkins: Yerkes National Primate Research Center, Emory University
Elizabeth A. Strobert: Yerkes National Primate Research Center, Emory University
Adriana E. Kajon: Infectious Disease Program, Lovelace Respiratory Research Institute
Ranjna Madan-Lala: Georgia Institute of Technology
Yury A. Bochkov: University of Wisconsin-Madison
James E. Gern: University of Wisconsin-Madison
Krishnendu Roy: Georgia Institute of Technology
Xiaoyan Lu: Centers for Disease Control and Prevention
Dean D. Erdman: Centers for Disease Control and Prevention
Paul Spearman: Emory University
Martin L. Moore: Emory University

Nature Communications, 2016, vol. 7, issue 1, 1-7

Abstract: Abstract As the predominant aetiological agent of the common cold, human rhinovirus (HRV) is the leading cause of human infectious disease. Early studies showed that a monovalent formalin-inactivated HRV vaccine can be protective, and virus-neutralizing antibodies (nAb) correlated with protection. However, co-circulation of many HRV types discouraged further vaccine efforts. Here, we test the hypothesis that increasing virus input titres in polyvalent inactivated HRV vaccine may result in broad nAb responses. We show that serum nAb against many rhinovirus types can be induced by polyvalent, inactivated HRVs plus alhydrogel (alum) adjuvant. Using formulations up to 25-valent in mice and 50-valent in rhesus macaques, HRV vaccine immunogenicity was related to sufficient quantity of input antigens, and valency was not a major factor for potency or breadth of the response. Thus, we have generated a vaccine capable of inducing nAb responses to numerous and diverse HRV types.

Date: 2016
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DOI: 10.1038/ncomms12838

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