FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties

Sarah A. Wolfe, Emily R. Workman, Chelcie F. Heaney, Farr Niere, Sanjeev Namjoshi, Luisa P. Cacheaux, Sean P. Farris, Michael R. Drew, Boris V. Zemelman, R. Adron Harris and Kimberly F. Raab-Graham ()
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Sarah A. Wolfe: Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin
Emily R. Workman: Center for Learning and Memory, The University of Texas at Austin
Chelcie F. Heaney: Center for Learning and Memory, The University of Texas at Austin
Farr Niere: Center for Learning and Memory, The University of Texas at Austin
Sanjeev Namjoshi: Center for Learning and Memory, The University of Texas at Austin
Luisa P. Cacheaux: Center for Learning and Memory, The University of Texas at Austin
Sean P. Farris: Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin
Michael R. Drew: Center for Learning and Memory, The University of Texas at Austin
Boris V. Zemelman: Center for Learning and Memory, The University of Texas at Austin
R. Adron Harris: Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin
Kimberly F. Raab-Graham: Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin

Nature Communications, 2016, vol. 7, issue 1, 1-13

Abstract: Abstract Alcohol promotes lasting neuroadaptive changes that may provide relief from depressive symptoms, often referred to as the self-medication hypothesis. However, the molecular/synaptic pathways that are shared by alcohol and antidepressants are unknown. In the current study, acute exposure to ethanol produced lasting antidepressant and anxiolytic behaviours. To understand the functional basis of these behaviours, we examined a molecular pathway that is activated by rapid antidepressants. Ethanol, like rapid antidepressants, alters γ-aminobutyric acid type B receptor (GABABR) expression and signalling, to increase dendritic calcium. Furthermore, new GABABRs are synthesized in response to ethanol treatment, requiring fragile-X mental retardation protein (FMRP). Ethanol-dependent changes in GABABR expression, dendritic signalling, and antidepressant efficacy are absent in Fmr1-knockout (KO) mice. These findings indicate that FMRP is an important regulator of protein synthesis following alcohol exposure, providing a molecular basis for the antidepressant efficacy of acute ethanol exposure.

Date: 2016
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DOI: 10.1038/ncomms12867

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