CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages

Milton Pereira, Panagiotis Tourlomousis, John Wright, Tom P. Monie () and Clare E. Bryant ()
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Milton Pereira: University of Cambridge
Panagiotis Tourlomousis: University of Cambridge
John Wright: University of Cambridge
Tom P. Monie: Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory
Clare E. Bryant: University of Cambridge

Nature Communications, 2016, vol. 7, issue 1, 1-13

Abstract: Abstract Interleukin-1β (IL-1β) is a proinflammatory cytokine required for host control of bacterial infections, and its production must be tightly regulated to prevent excessive inflammation. Here we show that caspase recruitment domain-containing protein 9 (CARD9), a protein associated with induction of proinflammatory cytokines by fungi, has a negative role on IL-1β production during bacterial infection. Specifically, in response to activation of the nucleotide oligomerization domain receptor pyrin-domain containing protein 3 (NLRP3) by Salmonella infection, CARD9 negatively regulates IL-1β by fine-tuning pro-IL-1β expression, spleen tyrosine kinase (SYK)-mediated NLRP3 activation and repressing inflammasome-associated caspase-8 activity. CARD9 is suppressed during Salmonella enterica serovar Typhimurium infection, facilitating increased IL-1β production. CARD9 is, therefore, a central signalling hub that coordinates a pathogen-specific host inflammatory response.

Date: 2016
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DOI: 10.1038/ncomms12874

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