FHF-independent conduction of action potentials along the leak-resistant cerebellar granule cell axon

Katarzyna Dover, Christopher Marra, Sergio Solinas, Marko Popovic, Sathyaa Subramaniyam, Dejan Zecevic, Egidio D’Angelo and Mitchell Goldfarb ()
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Katarzyna Dover: Hunter College of City University
Christopher Marra: Hunter College of City University
Sergio Solinas: Brain Connectivity Center, C. Mondino National Neurological Institute
Marko Popovic: Yale University School of Medicine
Sathyaa Subramaniyam: University of Pavia
Dejan Zecevic: Yale University School of Medicine
Egidio D’Angelo: Brain Connectivity Center, C. Mondino National Neurological Institute
Mitchell Goldfarb: Hunter College of City University

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract Neurons in vertebrate central nervous systems initiate and conduct sodium action potentials in distinct subcellular compartments that differ architecturally and electrically. Here, we report several unanticipated passive and active properties of the cerebellar granule cell’s unmyelinated axon. Whereas spike initiation at the axon initial segment relies on sodium channel (Nav)-associated fibroblast growth factor homologous factor (FHF) proteins to delay Nav inactivation, distal axonal Navs show little FHF association or FHF requirement for high-frequency transmission, velocity and waveforms of conducting action potentials. In addition, leak conductance density along the distal axon is estimated as

Date: 2016
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DOI: 10.1038/ncomms12895

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