Localized force application reveals mechanically sensitive domains of Piezo1

Jason Wu, Raman Goyal and Jörg Grandl ()
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Jason Wu: Duke University Medical Center
Raman Goyal: Duke University Medical Center
Jörg Grandl: Duke University Medical Center

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract Piezos are mechanically activated ion channels that function as sensors of touch and pressure in various cell types. However, the precise mechanism and structures mediating mechanical activation and subsequent inactivation have not yet been identified. Here we use magnetic nanoparticles as localized transducers of mechanical force in combination with pressure-clamp electrophysiology to identify mechanically sensitive domains important for activation and inactivation.

Date: 2016
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DOI: 10.1038/ncomms12939

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