Electronic control of H+ current in a bioprotonic device with Gramicidin A and Alamethicin

Zahra Hemmatian, Scott Keene, Erik Josberger, Takeo Miyake, Carina Arboleda, Jessica Soto-Rodríguez, François Baneyx and Marco Rolandi ()
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Zahra Hemmatian: University of California Santa Cruz
Scott Keene: University of Washington
Erik Josberger: University of Washington
Takeo Miyake: University of California Santa Cruz
Carina Arboleda: University of Washington
Jessica Soto-Rodríguez: University of Washington
François Baneyx: University of Washington
Marco Rolandi: University of California Santa Cruz

Nature Communications, 2016, vol. 7, issue 1, 1-8

Abstract: Abstract In biological systems, intercellular communication is mediated by membrane proteins and ion channels that regulate traffic of ions and small molecules across cell membranes. A bioelectronic device with ion channels that control ionic flow across a supported lipid bilayer (SLB) should therefore be ideal for interfacing with biological systems. Here, we demonstrate a biotic–abiotic bioprotonic device with Pd contacts that regulates proton (H+) flow across an SLB incorporating the ion channels Gramicidin A (gA) and Alamethicin (ALM). We model the device characteristics using the Goldman–Hodgkin–Katz (GHK) solution to the Nernst–Planck equation for transport across the membrane. We derive the permeability for an SLB integrating gA and ALM and demonstrate pH control as a function of applied voltage and membrane permeability. This work opens the door to integrating more complex H+ channels at the Pd contact interface to produce responsive biotic–abiotic devices with increased functionality.

Date: 2016
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DOI: 10.1038/ncomms12981

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