EIN2-dependent regulation of acetylation of histone H3K14 and non-canonical histone H3K23 in ethylene signalling

Fan Zhang, Bin Qi, Likai Wang, Bo Zhao, Siddharth Rode, Nathaniel D. Riggan, Joseph R. Ecker and Hong Qiao ()
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Fan Zhang: Institute for Cellular and Molecular Biology
Bin Qi: Institute for Cellular and Molecular Biology
Likai Wang: Institute for Cellular and Molecular Biology
Bo Zhao: The University of Texas at Austin
Siddharth Rode: The University of Texas at Austin
Nathaniel D. Riggan: The University of Texas at Austin
Joseph R. Ecker: Plant Biology Laboratory, The Salk Institute for Biological Studies
Hong Qiao: Institute for Cellular and Molecular Biology

Nature Communications, 2016, vol. 7, issue 1, 1-14

Abstract: Abstract Ethylene gas is essential for many developmental processes and stress responses in plants. EIN2 plays a key role in ethylene signalling but its function remains enigmatic. Here, we show that ethylene specifically elevates acetylation of histone H3K14 and the non-canonical acetylation of H3K23 in etiolated seedlings. The up-regulation of these two histone marks positively correlates with ethylene-regulated transcription activation, and the elevation requires EIN2. Both EIN2 and EIN3 interact with a SANT domain protein named EIN2 nuclear associated protein 1 (ENAP1), overexpression of which results in elevation of histone acetylation and enhanced ethylene-inducible gene expression in an EIN2-dependent manner. On the basis of these findings we propose a model where, in the presence of ethylene, the EIN2 C terminus contributes to downstream signalling via the elevation of acetylation at H3K14 and H3K23. ENAP1 may potentially mediate ethylene-induced histone acetylation via its interactions with EIN2 C terminus.

Date: 2016
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DOI: 10.1038/ncomms13018

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