Evolutionary interplay between sister cytochrome P450 genes shapes plasticity in plant metabolism

Zhenhua Liu, Raquel Tavares, Evan S. Forsythe, François André, Raphaël Lugan, Gabriella Jonasson, Stéphanie Boutet-Mercey, Takayuki Tohge, Mark A. Beilstein, Danièle Werck-Reichhart () and Hugues Renault
Additional contact information
Zhenhua Liu: Institute of Plant Molecular Biology, CNRS, University of Strasbourg
Raquel Tavares: Université Lyon 1, CNRS, UMR 5558, Laboratoire de Biométrie et Biologie Évolutive
Evan S. Forsythe: School of Plant Sciences, University of Arizona
François André: iBiTec-S/SB2SM, UMR 9198 CNRS, University Paris Sud, CEA Saclay
Raphaël Lugan: Institute of Plant Molecular Biology, CNRS, University of Strasbourg
Gabriella Jonasson: iBiTec-S/SB2SM, UMR 9198 CNRS, University Paris Sud, CEA Saclay
Stéphanie Boutet-Mercey: Institut Jean-Pierre Bourgin, UMR 1318 INRA-AgroParisTech, Saclay Plant Sciences RD10
Takayuki Tohge: Max-Planck-Institute of Molecular Plant Physiology
Mark A. Beilstein: School of Plant Sciences, University of Arizona
Danièle Werck-Reichhart: Institute of Plant Molecular Biology, CNRS, University of Strasbourg
Hugues Renault: Institute of Plant Molecular Biology, CNRS, University of Strasbourg

Nature Communications, 2016, vol. 7, issue 1, 1-10

Abstract: Abstract Expansion of the cytochrome P450 gene family is often proposed to have a critical role in the evolution of metabolic complexity, in particular in microorganisms, insects and plants. However, the molecular mechanisms underlying the evolution of this complexity are poorly understood. Here we describe the evolutionary history of a plant P450 retrogene, which emerged and underwent fixation in the common ancestor of Brassicales, before undergoing tandem duplication in the ancestor of Brassicaceae. Duplication leads first to gain of dual functions in one of the copies. Both sister genes are retained through subsequent speciation but eventually return to a single copy in two of three diverging lineages. In the lineage in which both copies are maintained, the ancestral functions are split between paralogs and a novel function arises in the copy under relaxed selection. Our work illustrates how retrotransposition and gene duplication can favour the emergence of novel metabolic functions.

Date: 2016
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DOI: 10.1038/ncomms13026

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