Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig

Jianzhao Liu, Yuanxiang Zhu, Guan-Zheng Luo, Xinxia Wang, Yanan Yue, Xiaona Wang, Xin Zong, Kai Chen, Hang Yin, Ye Fu, Dali Han, Yizhen Wang (), Dahua Chen () and Chuan He ()
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Jianzhao Liu: Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Yuanxiang Zhu: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Guan-Zheng Luo: Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Xinxia Wang: Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Yanan Yue: Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Xiaona Wang: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Xin Zong: Key Laboratory of Animal Nutrition and Feed Sciences, Ministry of Agriculture, College of Animal Sciences, Zhejiang University
Kai Chen: Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Hang Yin: Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Ye Fu: Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Dali Han: Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago
Yizhen Wang: Key Laboratory of Animal Nutrition and Feed Sciences, Ministry of Agriculture, College of Animal Sciences, Zhejiang University
Dahua Chen: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences
Chuan He: Institute for Biophysical Dynamics, Howard Hughes Medical Institute, The University of Chicago

Nature Communications, 2016, vol. 7, issue 1, 1-7

Abstract: Abstract DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1–0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.

Date: 2016
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DOI: 10.1038/ncomms13052

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