Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets

Hristo Georgiev, Inga Ravens, Charaf Benarafa, Reinhold Förster and Günter Bernhardt ()
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Hristo Georgiev: Institute of Immunology, Hannover Medical School
Inga Ravens: Institute of Immunology, Hannover Medical School
Charaf Benarafa: Theodor Kocher Institute, University of Bern
Reinhold Förster: Institute of Immunology, Hannover Medical School
Günter Bernhardt: Institute of Immunology, Hannover Medical School

Nature Communications, 2016, vol. 7, issue 1, 1-14

Abstract: Abstract Invariant natural killer T (iNKT) cells comprise a subpopulation of innate lymphocytes developing in thymus. A new model proposes subdividing murine iNKT cells into iNKT1, 2 and 17 cells. Here, we use transcriptome analyses of iNKT1, 2 and 17 subsets isolated from BALB/c and C57BL/6 thymi to identify candidate genes that may affect iNKT cell development, migration or function. We show that Fcɛr1γ is involved in generation of iNKT1 cells and that SerpinB1 modulates frequency of iNKT17 cells. Moreover, a considerable proportion of iNKT17 cells express IL-4 and IL-17 simultaneously. The results presented not only validate the usefulness of the iNKT1/2/17-concept but also provide new insights into iNKT cell biology.

Date: 2016
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DOI: 10.1038/ncomms13116

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