Genomic heterogeneity of multiple synchronous lung cancer

Yu Liu, Jianjun Zhang, Lin Li, Guangliang Yin, Jianhua Zhang, Shan Zheng, Hannah Cheung, Ning Wu, Ning Lu, Xizeng Mao, Longhai Yang, Jiexin Zhang, Li Zhang, Sahil Seth, Huang Chen, Xingzhi Song, Kan Liu, Yongqiang Xie, Lina Zhou, Chuanduo Zhao, Naijun Han, Wenting Chen, Susu Zhang, Longyun Chen, Wenjun Cai, Lin Li, Miaozhong Shen, Ningzhi Xu, Shujun Cheng, Huanming Yang, J. Jack Lee, Arlene Correa, Junya Fujimoto, Carmen Behrens, Chi-Wan Chow, William N. William, John V. Heymach, Waun Ki Hong, Stephen Swisher, Ignacio I. Wistuba, Jun Wang, Dongmei Lin, Xiangyang Liu, P. Andrew Futreal () and Yanning Gao ()
Additional contact information
Yu Liu: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Jianjun Zhang: The University of Texas MD Anderson Cancer Center
Lin Li: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Guangliang Yin: Beijing Genomics Institute
Jianhua Zhang: Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
Shan Zheng: Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Hannah Cheung: The University of Texas MD Anderson Cancer Center
Ning Wu: Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Ning Lu: Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Xizeng Mao: Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
Longhai Yang: Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Jiexin Zhang: The University of Texas MD Anderson Cancer Center
Li Zhang: Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Sahil Seth: Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
Huang Chen: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Xingzhi Song: Institute for Applied Cancer Science, The University of Texas MD Anderson Cancer Center
Kan Liu: Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Yongqiang Xie: Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Lina Zhou: Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Chuanduo Zhao: Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Naijun Han: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Wenting Chen: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Susu Zhang: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Longyun Chen: Beijing Genomics Institute
Wenjun Cai: Beijing Genomics Institute
Lin Li: Beijing Genomics Institute
Miaozhong Shen: Beijing Genomics Institute
Ningzhi Xu: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Shujun Cheng: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Huanming Yang: Beijing Genomics Institute
J. Jack Lee: The University of Texas MD Anderson Cancer Center
Arlene Correa: The University of Texas MD Anderson Cancer Center
Junya Fujimoto: The University of Texas MD Anderson Cancer Center
Carmen Behrens: The University of Texas MD Anderson Cancer Center
Chi-Wan Chow: The University of Texas MD Anderson Cancer Center
William N. William: The University of Texas MD Anderson Cancer Center
John V. Heymach: The University of Texas MD Anderson Cancer Center
Waun Ki Hong: The University of Texas MD Anderson Cancer Center
Stephen Swisher: The University of Texas MD Anderson Cancer Center
Ignacio I. Wistuba: The University of Texas MD Anderson Cancer Center
Jun Wang: Beijing Genomics Institute
Dongmei Lin: Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
Xiangyang Liu: Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences
P. Andrew Futreal: The University of Texas MD Anderson Cancer Center
Yanning Gao: State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences

Nature Communications, 2016, vol. 7, issue 1, 1-8

Abstract: Abstract Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent tumours. In this study we analyse genomic profiles of 15 lung adenocarcinomas and one regional lymph node metastasis from 6 patients with MSLC. All 15 lung tumours demonstrate distinct genomic profiles, suggesting all are independent primary tumours, which are consistent with comprehensive histopathological assessment in 5 of the 6 patients. Lung tumours of the same individuals are no more similar to each other than are lung adenocarcinomas of different patients from TCGA cohort matched for tumour size and smoking status. Several known cancer-associated genes have different mutations in different tumours from the same patients. These findings suggest that in the context of identical constitutional genetic background and environmental exposure, different lung cancers in the same individual may have distinct genomic profiles and can be driven by distinct molecular events.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/ncomms13200 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13200

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms13200

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().