DciA is an ancestral replicative helicase operator essential for bacterial replication initiation

Pierre Brézellec, Isabelle Vallet-Gely, Christophe Possoz, Sophie Quevillon-Cheruel and Jean-Luc Ferat ()
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Pierre Brézellec: Universite de Versailles Saint-Quentin
Isabelle Vallet-Gely: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris‐Sud, Université Paris‐Saclay
Christophe Possoz: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris‐Sud, Université Paris‐Saclay
Sophie Quevillon-Cheruel: Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris‐Sud, Université Paris‐Saclay
Jean-Luc Ferat: Universite de Versailles Saint-Quentin

Nature Communications, 2016, vol. 7, issue 1, 1-7

Abstract: Abstract Delivery of the replicative helicase onto DNA is an essential step in the initiation of replication. In bacteria, DnaC (in Escherichia coli) and DnaI (in Bacillus subtilis) are representative of the two known mechanisms that assist the replicative helicase at this stage. Here, we establish that these two strategies cannot be regarded as prototypical of the bacterial domain since dnaC and dnaI (dna[CI]) are present in only a few bacterial phyla. We show that dna[CI] was domesticated at least seven times through evolution in bacteria and at the expense of one gene, which we rename dciA (dna[CI] antecedent), suggesting that DciA and Dna[CI] share a common function. We validate this hypothesis by establishing in Pseudomonas aeruginosa that DciA possesses the attributes of the replicative helicase-operating proteins associated with replication initiation.

Date: 2016
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DOI: 10.1038/ncomms13271

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