Bioengineering of injectable encapsulated aggregates of pluripotent stem cells for therapy of myocardial infarction

Shuting Zhao, Zhaobin Xu, Hai Wang, Benjamin E. Reese, Liubov V. Gushchina, Meng Jiang, Pranay Agarwal, Jiangsheng Xu, Mingjun Zhang, Rulong Shen, Zhenguo Liu (), Noah Weisleder () and Xiaoming He ()
Additional contact information
Shuting Zhao: The Ohio State University
Zhaobin Xu: Davis Heart and Lung Research Institute, The Ohio State University
Hai Wang: The Ohio State University
Benjamin E. Reese: The Ohio State University
Liubov V. Gushchina: Davis Heart and Lung Research Institute, The Ohio State University
Meng Jiang: Davis Heart and Lung Research Institute, The Ohio State University
Pranay Agarwal: The Ohio State University
Jiangsheng Xu: The Ohio State University
Mingjun Zhang: The Ohio State University
Rulong Shen: The Ohio State University
Zhenguo Liu: Davis Heart and Lung Research Institute, The Ohio State University
Noah Weisleder: Davis Heart and Lung Research Institute, The Ohio State University
Xiaoming He: The Ohio State University

Nature Communications, 2016, vol. 7, issue 1, 1-12

Abstract: Abstract It is difficult to achieve minimally invasive injectable cell delivery while maintaining high cell retention and animal survival for in vivo stem cell therapy of myocardial infarction. Here we show that pluripotent stem cell aggregates pre-differentiated into the early cardiac lineage and encapsulated in a biocompatible and biodegradable micromatrix, are suitable for injectable delivery. This method significantly improves the survival of the injected cells by more than six-fold compared with the conventional practice of injecting single cells, and effectively prevents teratoma formation. Moreover, this method significantly enhances cardiac function and survival of animals after myocardial infarction, as a result of a localized immunosuppression effect of the micromatrix and the in situ cardiac regeneration by the injected cells.

Date: 2016
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DOI: 10.1038/ncomms13306

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