Vasculogenic mimicry in small cell lung cancer

Stuart C. Williamson, Robert L. Metcalf, Francesca Trapani, Sumitra Mohan, Jenny Antonello, Benjamin Abbott, Hui Sun Leong, Christopher P. E. Chester, Nicole Simms, Radoslaw Polanski, Daisuke Nonaka, Lynsey Priest, Alberto Fusi, Fredrika Carlsson, Anders Carlsson, Mary J. C. Hendrix, Richard E. B. Seftor, Elisabeth A. Seftor, Dominic G. Rothwell, Andrew Hughes, James Hicks, Crispin Miller, Peter Kuhn, Ged Brady, Kathryn L. Simpson, Fiona H. Blackhall and Caroline Dive ()
Additional contact information
Stuart C. Williamson: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Robert L. Metcalf: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Francesca Trapani: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Sumitra Mohan: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Jenny Antonello: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Benjamin Abbott: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Hui Sun Leong: Computational Biology Support Team, Cancer Research UK Manchester Institute
Christopher P. E. Chester: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Nicole Simms: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Radoslaw Polanski: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Daisuke Nonaka: The Christie NHS Foundation Trust
Lynsey Priest: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Alberto Fusi: The Christie NHS Foundation Trust
Fredrika Carlsson: University of Southern California Dornsife
Anders Carlsson: University of Southern California Dornsife
Mary J. C. Hendrix: Stanley Manne Children’s Research Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
Richard E. B. Seftor: Stanley Manne Children’s Research Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
Elisabeth A. Seftor: Stanley Manne Children’s Research Institute, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine
Dominic G. Rothwell: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Andrew Hughes: The Institute of Cancer Sciences, University of Manchester
James Hicks: University of Southern California Dornsife
Crispin Miller: RNA Biology Group, Cancer Research UK Manchester Institute
Peter Kuhn: University of Southern California Dornsife
Ged Brady: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Kathryn L. Simpson: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute
Fiona H. Blackhall: The Christie NHS Foundation Trust
Caroline Dive: Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute

Nature Communications, 2016, vol. 7, issue 1, 1-14

Abstract: Abstract Small cell lung cancer (SCLC) is characterized by prevalent circulating tumour cells (CTCs), early metastasis and poor prognosis. We show that SCLC patients (37/38) have rare CTC subpopulations co-expressing vascular endothelial-cadherin (VE-cadherin) and cytokeratins consistent with vasculogenic mimicry (VM), a process whereby tumour cells form ‘endothelial-like’ vessels. Single-cell genomic analysis reveals characteristic SCLC genomic changes in both VE-cadherin-positive and -negative CTCs. Higher levels of VM are associated with worse overall survival in 41 limited-stage patients’ biopsies (P

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/ncomms13322 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13322

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms13322

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().