A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Janina S. Ried, Janina Jeff M., Audrey Y. Chu, Jennifer L. Bragg-Gresham, Jenny van Dongen, Jennifer E. Huffman, Tarunveer S. Ahluwalia, Gemma Cadby, Niina Eklund, Joel Eriksson, Tõnu Esko, Mary F. Feitosa, Anuj Goel, Mathias Gorski, Caroline Hayward, Nancy L. Heard-Costa, Anne U. Jackson, Eero Jokinen, Stavroula Kanoni, Kati Kristiansson, Zoltán Kutalik, Jari Lahti, Jian'an Luan, Reedik Mägi, Anubha Mahajan, Massimo Mangino, Carolina Medina-Gomez, Keri L. Monda, Ilja M. Nolte, Louis Pérusse, Inga Prokopenko, Lu Qi, Lynda M. Rose, Erika Salvi, Megan T. Smith, Harold Snieder, Alena Stančáková, Yun Ju Sung, Ioanna Tachmazidou, Alexander Teumer, Gudmar Thorleifsson, Pim van der Harst, Ryan W. Walker, Sophie R. Wang, Sarah H. Wild, Sara M. Willems, Andrew Wong, Weihua Zhang, Eva Albrecht, Alexessander Couto Alves, Stephan J. L. Bakker, Cristina Barlassina, Traci M. Bartz, John Beilby, Claire Bellis, Richard N. Bergman, Sven Bergmann, John Blangero, Matthias Blüher, Eric Boerwinkle, Lori L. Bonnycastle, Stefan R. Bornstein, Marcel Bruinenberg, Harry Campbell, Yii- Der Ida Chen, Charleston W. K. Chiang, Peter S. Chines, Francis S Collins, Fracensco Cucca, L Adrienne Cupples, Francesca D’Avila, Eco J .C. de Geus, George Dedoussis, Maria Dimitriou, Angela Döring, Johan G. Eriksson, Aliki-Eleni Farmaki, Martin Farrall, Teresa Ferreira, Krista Fischer, Nita G. Forouhi, Nele Friedrich, Anette Prior Gjesing, Nicola Glorioso, Mariaelisa Graff, Harald Grallert, Niels Grarup, Jürgen Gräßler, Jagvir Grewal, Anders Hamsten, Marie Neergaard Harder, Catharina A. Hartman, Maija Hassinen, Nicholas Hastie, Andrew Tym Hattersley, Aki S. Havulinna, Markku Heliövaara, Hans Hillege, Albert Hofman, Oddgeir Holmen, Georg Homuth, Jouke-Jan Hottenga, Jennie Hui, Lise Lotte Husemoen, Pirro G. Hysi, Aaron Isaacs, Till Ittermann, Shapour Jalilzadeh, Alan L. James, Torben Jørgensen, Pekka Jousilahti, Antti Jula, Johanne Marie Justesen, Anne E. Justice, Mika Kähönen, Maria Karaleftheri, Kay Tee Khaw, Sirkka M. Keinanen-Kiukaanniemi, Leena Kinnunen, Paul B. Knekt, Heikki A. Koistinen, Ivana Kolcic, Ishminder K. Kooner, Seppo Koskinen, Peter Kovacs, Theodosios Kyriakou, Tomi Laitinen, Claudia Langenberg, Alexandra M. Lewin, Peter Lichtner, Cecilia M. Lindgren, Jaana Lindström, Allan Linneberg, Roberto Lorbeer, Mattias Lorentzon, Robert Luben, Valeriya Lyssenko, Satu Männistö, Paolo Manunta, Irene Mateo Leach, Wendy L. McArdle, Barbara Mcknight, Karen L. Mohlke, Evelin Mihailov, Lili Milani, Rebecca Mills, May E. Montasser, Andrew P. Morris, Gabriele Müller, Arthur W. Musk, Narisu Narisu, Ken K. Ong, Ben A. Oostra, Clive Osmond, Aarno Palotie, James S. Pankow, Lavinia Paternoster, Brenda W. Penninx, Irene Pichler, Maria G. Pilia, Ozren Polašek, Peter P. Pramstaller, Olli T Raitakari, Tuomo Rankinen, D. C. Rao, Nigel W. Rayner, Rasmus Ribel-Madsen, Treva K. Rice, Marcus Richards, Paul M. Ridker, Fernando Rivadeneira, Kathy A. Ryan, Serena Sanna, Mark A. Sarzynski, Salome Scholtens, Robert A. Scott, Sylvain Sebert, Lorraine Southam, Thomas Hempel Sparsø, Valgerdur Steinthorsdottir, Kathleen Stirrups, Ronald P. Stolk, Konstantin Strauch, Heather M. Stringham, Morris A. Swertz, Amy J. Swift, Anke Tönjes, Emmanouil Tsafantakis, Peter J. van der Most, Jana V. Van Vliet-Ostaptchouk, Liesbeth Vandenput, Erkki Vartiainen, Cristina Venturini, Niek Verweij, Jorma S. Viikari, Veronique Vitart, Marie-Claude Vohl, Judith M. Vonk, Gérard Waeber, Elisabeth Widén, Gonneke Willemsen, Tom Wilsgaard, Thomas W. Winkler, Alan F. Wright, Laura M. Yerges-Armstrong, Jing Hua Zhao, M. Carola Zillikens, Dorret I. Boomsma, Claude Bouchard, John C. Chambers, Daniel I. Chasman, Daniele Cusi, Ron T. Gansevoort, Christian Gieger, Torben Hansen, Andrew A. Hicks, Frank Hu, Kristian Hveem, Marjo-Riitta Jarvelin, Eero Kajantie, Jaspal S. Kooner, Diana Kuh, Johanna Kuusisto, Markku Laakso, Timo A. Lakka, Terho Lehtimäki, Andres Metspalu, Inger Njølstad, Claes Ohlsson, Albertine J. Oldehinkel, Lyle J. Palmer, Oluf Pedersen, Markus Perola, Annette Peters, Bruce M. Psaty, Hannu Puolijoki, Rainer Rauramaa, Igor Rudan, Veikko Salomaa, Peter E. H. Schwarz, Alan R. Shudiner, Jan H. Smit, Thorkild I. A. Sørensen, Timothy D. Spector, Kari Stefansson, Michael Stumvoll, Angelo Tremblay, Jaakko Tuomilehto, André G. Uitterlinden, Matti Uusitupa, Uwe Völker, Peter Vollenweider, Nicholas J. Wareham, Hugh Watkins, James F. Wilson, Eleftheria Zeggini, Goncalo R. Abecasis, Michael Boehnke, Ingrid B. Borecki, Panos Deloukas, Cornelia M. van Duijn, Caroline Fox, Leif C. Groop, Iris M. Heid, David J. Hunter, Robert C. Kaplan, Mark I. McCarthy, Kari E. North, Jeffrey R. O'Connell, David Schlessinger, Unnur Thorsteinsdottir, David P. Strachan, Timothy Frayling, Joel N. Hirschhorn, Martina Müller-Nurasyid () and Ruth J. F. Loos ()
Additional contact information
Janina S. Ried: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health
Janina Jeff M.: The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai
Audrey Y. Chu: Brigham and Women's Hospital
Jennifer L. Bragg-Gresham: Kidney Epidemiology and Cost Center, Internal Medicine-Nephrology, University of Michigan
Jenny van Dongen: VU University
Jennifer E. Huffman: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Tarunveer S. Ahluwalia: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Gemma Cadby: Centre for Genetic Origins of Health and Disease, University of Western Australia
Niina Eklund: National Institute for Health and Welfare (THL)
Joel Eriksson: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
Tõnu Esko: Broad Institute of the Massachusetts Institute of Technology and Harvard University
Mary F. Feitosa: Washington University School of Medicine
Anuj Goel: University of Oxford
Mathias Gorski: University Hospital Regensburg
Caroline Hayward: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Nancy L. Heard-Costa: National Heart, Lung, and Blood Institute, the Framingham Heart Study
Anne U. Jackson: Center for Statistical Genetics, University of Michigan
Eero Jokinen: Hospital for Children and Adolescents, University of Helsinki
Stavroula Kanoni: Wellcome Trust Sanger Institute, Human Genetics
Kati Kristiansson: National Institute for Health and Welfare (THL)
Zoltán Kutalik: Swiss Institute of Bioinformatics
Jari Lahti: Folkhälsan Research Centre
Jian'an Luan: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
Reedik Mägi: Estonian Genome Center, University of Tartu
Anubha Mahajan: Wellcome Trust Centre for Human Genetics, University of Oxford
Massimo Mangino: King's College London
Carolina Medina-Gomez: Erasmus Medical Center
Keri L. Monda: University of North Carolina at Chapel Hill
Ilja M. Nolte: University of Groningen, University Medical Center Groningen
Louis Pérusse: Laval University
Inga Prokopenko: Wellcome Trust Centre for Human Genetics, University of Oxford
Lu Qi: Brigham and Women’s Hospital and Harvard Medical School
Lynda M. Rose: Brigham and Women's Hospital
Erika Salvi: University of Milano at San Paolo Hospital
Megan T. Smith: University of Washington
Harold Snieder: University of Groningen, University Medical Center Groningen
Alena Stančáková: University of Eastern Finland and Kuopio University Hospital
Yun Ju Sung: Washington University School of Medicine
Ioanna Tachmazidou: Wellcome Trust Sanger Institute, Human Genetics
Alexander Teumer: Institute for Community Medicine, University Medicine Greifswald
Gudmar Thorleifsson: deCODE Genetics, Amgen inc.
Pim van der Harst: Durrer Center for Cardiogenetic Research, Interuniversity Cardiology Institute Netherlands-Netherlands Heart Institute
Ryan W. Walker: The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai
Sophie R. Wang: Harvard Medical School
Sarah H. Wild: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Sara M. Willems: Genetic Epidemiology Unit, Erasmus University Medical Center
Andrew Wong: MRC Unit for Lifelong Health & Ageing at UCL
Weihua Zhang: Imperial College London
Eva Albrecht: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health
Alexessander Couto Alves: MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College
Stephan J. L. Bakker: University of Groningen, University Medical Center Groningen
Cristina Barlassina: University of Milano at San Paolo Hospital
Traci M. Bartz: University of Washington
John Beilby: Pathwest Laboratory Medicine of Western Australia
Claire Bellis: Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology
Richard N. Bergman: Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center
Sven Bergmann: Swiss Institute of Bioinformatics
John Blangero: South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley
Matthias Blüher: University of Leipzig, IFB Adiposity Diseases
Eric Boerwinkle: Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center
Lori L. Bonnycastle: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
Stefan R. Bornstein: Medical Faculty Carl Gustav Carus, University of Dresden
Marcel Bruinenberg: University of Groningen, University Medical Center Groningen, The LifeLines Cohort Study
Harry Campbell: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Yii- Der Ida Chen: Los Angeles BioMedical Resesarch Institute at Harbor-UCLA Medical Center
Charleston W. K. Chiang: University of California
Peter S. Chines: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
Francis S Collins: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
Fracensco Cucca: University of Sassari
L Adrienne Cupples: National Heart, Lung, and Blood Institute, the Framingham Heart Study
Francesca D’Avila: University of Milano at San Paolo Hospital
Eco J .C. de Geus: VU University
George Dedoussis: School of Health Science and Education, Harokopio University
Maria Dimitriou: Wellcome Trust Sanger Institute, Human Genetics
Angela Döring: Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health
Johan G. Eriksson: Folkhälsan Research Centre
Aliki-Eleni Farmaki: School of Health Science and Education, Harokopio University
Martin Farrall: University of Oxford
Teresa Ferreira: Wellcome Trust Centre for Human Genetics, University of Oxford
Krista Fischer: Estonian Genome Center, University of Tartu
Nita G. Forouhi: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
Nele Friedrich: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald
Anette Prior Gjesing: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Nicola Glorioso: Hypertension and Related Disease Centre, AOU-University of Sassari
Mariaelisa Graff: University of North Carolina at Chapel Hill
Harald Grallert: Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health
Niels Grarup: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Jürgen Gräßler: Pathobiochemistry, Technische Universitaet
Jagvir Grewal: Imperial College London
Anders Hamsten: Karolinska Institutet
Marie Neergaard Harder: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Catharina A. Hartman: University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion Regulation
Maija Hassinen: Kuopio Research Institute of Exercise Medicine
Nicholas Hastie: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Andrew Tym Hattersley: Institue of Biomedical & Clinical Science, University of Exeter, Barrack Road, Exeter EX2 5DW, UK
Aki S. Havulinna: National Institute for Health and Welfare (THL)
Markku Heliövaara: National Institute for Health and Welfare (THL)
Hans Hillege: University of Groningen, University Medical Center Groningen
Albert Hofman: Erasmus Medical Center
Oddgeir Holmen: Norwegian University of Science and Technology
Georg Homuth: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Jouke-Jan Hottenga: VU University
Jennie Hui: Pathwest Laboratory Medicine of Western Australia
Lise Lotte Husemoen: Research Centre for Prevention and Health, Glostrup Hospital
Pirro G. Hysi: King's College London
Aaron Isaacs: Genetic Epidemiology Unit, Erasmus University Medical Center
Till Ittermann: Institute for Community Medicine, University Medicine Greifswald
Shapour Jalilzadeh: University of Oxford
Alan L. James: Sir Charles Gairdner Hospital
Torben Jørgensen: Faculty of Health and Medical Sciences, University of Copenhagen
Pekka Jousilahti: National Institute for Health and Welfare (THL)
Antti Jula: National Institute for Health and Welfare (THL)
Johanne Marie Justesen: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Anne E. Justice: University of North Carolina at Chapel Hill
Mika Kähönen: Tampere University Hospital
Maria Karaleftheri: Echinos Medical Centre
Kay Tee Khaw: Clinical Gerontology Unit, Box 251, Addenbrooke's Hospital, Hills Road
Sirkka M. Keinanen-Kiukaanniemi: Faculty of Medicine, Institute of Health Sciences, University of Oulu
Leena Kinnunen: National Institute for Health and Welfare
Paul B. Knekt: National Institute for Health and Welfare (THL)
Heikki A. Koistinen: National Institute for Health and Welfare
Ivana Kolcic: Faculty of Medicine, University of Split
Ishminder K. Kooner: Ealing Hospital NHS Trust
Seppo Koskinen: National Institute for Health and Welfare (THL)
Peter Kovacs: University of Leipzig, IFB Adiposity Diseases
Theodosios Kyriakou: University of Oxford
Tomi Laitinen: Kuopio University Hospital
Claudia Langenberg: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
Alexandra M. Lewin: MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College
Peter Lichtner: Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health
Cecilia M. Lindgren: Broad Institute of the Massachusetts Institute of Technology and Harvard University
Jaana Lindström: National Institute for Health and Welfare (THL)
Allan Linneberg: Research Centre for Prevention and Health, Glostrup Hospital
Roberto Lorbeer: Institute for Community Medicine, University Medicine Greifswald
Mattias Lorentzon: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
Robert Luben: Strangeways Research Laboratory Wort's Causeway
Valeriya Lyssenko: Steno Diabetes Center A/S
Satu Männistö: National Institute for Health and Welfare (THL)
Paolo Manunta: Chair of Nephrology, Università Vita Salute San Raffaele and Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute
Irene Mateo Leach: University of Groningen, University Medical Center Groningen
Wendy L. McArdle: School of Social and Community Medicine, University of Bristol
Barbara Mcknight: University of Washington
Karen L. Mohlke: University of North Carolina
Evelin Mihailov: Estonian Genome Center, University of Tartu
Lili Milani: Estonian Genome Center, University of Tartu
Rebecca Mills: Ealing Hospital NHS Trust
May E. Montasser: Diabetes & Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine
Andrew P. Morris: Wellcome Trust Centre for Human Genetics, University of Oxford
Gabriele Müller: Center for Evidence Based Healthcare, University of Dresden, Medical Faculty Carl Gustav Carus
Arthur W. Musk: Sir Charles Gairdner Hospital
Narisu Narisu: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
Ken K. Ong: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
Ben A. Oostra: Genetic Epidemiology Unit, Erasmus University Medical Center
Clive Osmond: MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital
Aarno Palotie: Institute for Molecular Medicine Finland, University of Helsinki
James S. Pankow: School of Public Health, University of Minnesota
Lavinia Paternoster: MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol
Brenda W. Penninx: VU University Medical Center
Irene Pichler: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
Maria G. Pilia: Istituto di Ricerca Genetica e Biomedica, CNR
Ozren Polašek: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Peter P. Pramstaller: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
Olli T Raitakari: Turku University Hospital
Tuomo Rankinen: Human Genomics Laboratory, Pennington Biomedical Research Center
D. C. Rao: Washington University School of Medicine
Nigel W. Rayner: Wellcome Trust Centre for Human Genetics, University of Oxford
Rasmus Ribel-Madsen: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Treva K. Rice: Washington University School of Medicine
Marcus Richards: Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital
Paul M. Ridker: Brigham and Women's Hospital
Fernando Rivadeneira: Erasmus Medical Center
Kathy A. Ryan: Diabetes & Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine
Serena Sanna: Istituto di Ricerca Genetica e Biomedica, CNR
Mark A. Sarzynski: Human Genomics Laboratory, Pennington Biomedical Research Center
Salome Scholtens: University of Groningen, University Medical Center Groningen
Robert A. Scott: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
Sylvain Sebert: School of Public Health, Imperial College London
Lorraine Southam: Wellcome Trust Centre for Human Genetics, University of Oxford
Thomas Hempel Sparsø: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Valgerdur Steinthorsdottir: deCODE Genetics, Amgen inc.
Kathleen Stirrups: Wellcome Trust Sanger Institute, Human Genetics
Ronald P. Stolk: University of Groningen, University Medical Center Groningen
Konstantin Strauch: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health
Heather M. Stringham: Center for Statistical Genetics, University of Michigan
Morris A. Swertz: University of Groningen, University Medical Center Groningen
Amy J. Swift: Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH
Anke Tönjes: University of Leipzig
Emmanouil Tsafantakis: Anogia Medical Centre
Peter J. van der Most: University of Groningen, University Medical Center Groningen
Jana V. Van Vliet-Ostaptchouk: University of Groningen, University Medical Center Groningen
Liesbeth Vandenput: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
Erkki Vartiainen: National Institute for Health and Welfare (THL)
Cristina Venturini: King's College London
Niek Verweij: University of Groningen, University Medical Center Groningen
Jorma S. Viikari: University of Turku
Veronique Vitart: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Marie-Claude Vohl: Institute of Nutrition and Functional Foods, Laval University
Judith M. Vonk: University of Groningen, University Medical Center Groningen
Gérard Waeber: University Hospital Lausanne (CHUV) and University of Lausanne
Elisabeth Widén: Institute for Molecular Medicine Finland, University of Helsinki
Gonneke Willemsen: VU University
Tom Wilsgaard: Faculty of Health Sciences, University of Tromsø
Thomas W. Winkler: Institute of Epidemiology and Preventive Medicine, University of Regensburg
Alan F. Wright: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Laura M. Yerges-Armstrong: Diabetes & Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine
Jing Hua Zhao: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
M. Carola Zillikens: Erasmus Medical Center
Dorret I. Boomsma: VU University
Claude Bouchard: Human Genomics Laboratory, Pennington Biomedical Research Center
John C. Chambers: Imperial College London
Daniel I. Chasman: Brigham and Women's Hospital
Daniele Cusi: University of Milano at San Paolo Hospital
Ron T. Gansevoort: University of Groningen, University Medical Center Groningen
Christian Gieger: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health
Torben Hansen: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Andrew A. Hicks: Center for Biomedicine, European Academy Bozen/Bolzano (EURAC)
Frank Hu: Brigham and Women’s Hospital and Harvard Medical School
Kristian Hveem: Norwegian University of Science and Technology
Marjo-Riitta Jarvelin: Biocenter Oulu, University of Oulu
Eero Kajantie: National Institute for Health and Welfare (THL)
Jaspal S. Kooner: Ealing Hospital NHS Trust
Diana Kuh: MRC Unit for Lifelong Health & Ageing at UCL
Johanna Kuusisto: University of Eastern Finland and Kuopio University Hospital
Markku Laakso: University of Eastern Finland and Kuopio University Hospital
Timo A. Lakka: Kuopio Research Institute of Exercise Medicine
Terho Lehtimäki: University of Tampere School of Medicine
Andres Metspalu: Estonian Genome Center, University of Tartu
Inger Njølstad: Faculty of Health Sciences, University of Tromsø
Claes Ohlsson: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
Albertine J. Oldehinkel: University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion Regulation
Lyle J. Palmer: School of Public Health, University of Adelaide
Oluf Pedersen: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Markus Perola: National Institute for Health and Welfare (THL)
Annette Peters: Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health
Bruce M. Psaty: Cardiovascular Health Research Unit, University of Washington
Hannu Puolijoki: South Ostrobothnia Central Hospital
Rainer Rauramaa: Kuopio Research Institute of Exercise Medicine
Igor Rudan: Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh
Veikko Salomaa: National Institute for Health and Welfare (THL)
Peter E. H. Schwarz: Medical Faculty Carl Gustav Carus, University of Dresden
Alan R. Shudiner: Diabetes & Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine
Jan H. Smit: VU University Medical Center
Thorkild I. A. Sørensen: Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen
Timothy D. Spector: King's College London
Kari Stefansson: deCODE Genetics, Amgen inc.
Michael Stumvoll: University of Leipzig, IFB Adiposity Diseases
Angelo Tremblay: Laval University
Jaakko Tuomilehto: Diabetes Prevention Unit, National Institute for Health and Welfare
André G. Uitterlinden: Erasmus Medical Center
Matti Uusitupa: University of Eastern Finland
Uwe Völker: Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald
Peter Vollenweider: University Hospital Lausanne (CHUV) and University of Lausanne
Nicholas J. Wareham: MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, University of Cambridge, Cambridge Biomedical Campus
Hugh Watkins: University of Oxford
James F. Wilson: MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
Eleftheria Zeggini: Wellcome Trust Sanger Institute, Human Genetics
Goncalo R. Abecasis: Center for Statistical Genetics, University of Michigan
Michael Boehnke: Center for Statistical Genetics, University of Michigan
Ingrid B. Borecki: Washington University School of Medicine
Panos Deloukas: William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
Cornelia M. van Duijn: Genetic Epidemiology Unit, Erasmus University Medical Center
Caroline Fox: National Heart, Lung, and Blood Institute, the Framingham Heart Study
Leif C. Groop: Diabetes & Endocrinology Unit, Lund University
Iris M. Heid: Institute of Epidemiology and Preventive Medicine, University of Regensburg
David J. Hunter: Broad Institute of the Massachusetts Institute of Technology and Harvard University
Robert C. Kaplan: Albert Einstein College of Medicine
Mark I. McCarthy: Wellcome Trust Centre for Human Genetics, University of Oxford
Kari E. North: Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill
Jeffrey R. O'Connell: Diabetes & Nutrition, Program for Personalized and Genomic Medicine, University of Maryland School of Medicine
David Schlessinger: National Institute on Aging, National Institutes of Health
Unnur Thorsteinsdottir: deCODE Genetics, Amgen inc.
David P. Strachan: Population Health Research Institute, St George's, University of London
Timothy Frayling: Genetics of Complex Traits, University of Exeter Medical School, University of Exeter
Joel N. Hirschhorn: Broad Institute of the Massachusetts Institute of Technology and Harvard University
Martina Müller-Nurasyid: Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health
Ruth J. F. Loos: The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai

Nature Communications, 2016, vol. 7, issue 1, 1-11

Abstract: Abstract Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.

Date: 2016
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DOI: 10.1038/ncomms13357

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