Tetrapod limb and sarcopterygian fin regeneration share a core genetic programme

Acacio F. Nogueira, Carinne M. Costa, Jamily Lorena, Rodrigo N. Moreira, Gabriela N. Frota-Lima, Carolina Furtado, Mark Robinson, Chris T. Amemiya, Sylvain Darnet and Igor Schneider ()
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Acacio F. Nogueira: Instituto de Ciências Biológicas, Universidade Federal do Pará
Carinne M. Costa: Instituto de Ciências Biológicas, Universidade Federal do Pará
Jamily Lorena: Instituto de Ciências Biológicas, Universidade Federal do Pará
Rodrigo N. Moreira: Instituto de Ciências Biológicas, Universidade Federal do Pará
Gabriela N. Frota-Lima: Instituto de Ciências Biológicas, Universidade Federal do Pará
Carolina Furtado: Unidade Genômica, Programa de Genética, Instituto Nacional do Câncer
Mark Robinson: Benaroya Research Institute at Virginia Mason
Chris T. Amemiya: Benaroya Research Institute at Virginia Mason
Sylvain Darnet: Instituto de Ciências Biológicas, Universidade Federal do Pará
Igor Schneider: Instituto de Ciências Biológicas, Universidade Federal do Pará

Nature Communications, 2016, vol. 7, issue 1, 1-9

Abstract: Abstract Salamanders are the only living tetrapods capable of fully regenerating limbs. The discovery of salamander lineage-specific genes (LSGs) expressed during limb regeneration suggests that this capacity is a salamander novelty. Conversely, recent paleontological evidence supports a deeper evolutionary origin, before the occurrence of salamanders in the fossil record. Here we show that lungfishes, the sister group of tetrapods, regenerate their fins through morphological steps equivalent to those seen in salamanders. Lungfish de novo transcriptome assembly and differential gene expression analysis reveal notable parallels between lungfish and salamander appendage regeneration, including strong downregulation of muscle proteins and upregulation of oncogenes, developmental genes and lungfish LSGs. MARCKS-like protein (MLP), recently discovered as a regeneration-initiating molecule in salamander, is likewise upregulated during early stages of lungfish fin regeneration. Taken together, our results lend strong support for the hypothesis that tetrapods inherited a bona fide limb regeneration programme concomitant with the fin-to-limb transition.

Date: 2016
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DOI: 10.1038/ncomms13364

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