Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma

Fang Sun, Hsiang-Chieh Hung, Andrew Sinclair, Peng Zhang, Tao Bai, Daniel David Galvan, Priyesh Jain, Bowen Li, Shaoyi Jiang () and Qiuming Yu ()
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Fang Sun: University of Washington
Hsiang-Chieh Hung: University of Washington
Andrew Sinclair: University of Washington
Peng Zhang: University of Washington
Tao Bai: University of Washington
Daniel David Galvan: University of Washington
Priyesh Jain: University of Washington
Bowen Li: University of Washington
Shaoyi Jiang: University of Washington
Qiuming Yu: University of Washington

Nature Communications, 2016, vol. 7, issue 1, 1-9

Abstract: Abstract Surface-enhanced Raman spectroscopy (SERS) is an ultrasensitive analytical technique with molecular specificity, making it an ideal candidate for therapeutic drug monitoring (TDM). However, in critical diagnostic media including blood, nonspecific protein adsorption coupled with weak surface affinities and small Raman activities of many analytes hinder the TDM application of SERS. Here we report a hierarchical surface modification strategy, first by coating a gold surface with a self-assembled monolayer (SAM) designed to attract or probe for analytes and then by grafting a non-fouling zwitterionic polymer brush layer to effectively repel protein fouling. We demonstrate how this modification can enable TDM applications by quantitatively and dynamically measuring the concentrations of several analytes—including an anticancer drug (doxorubicin), several TDM-requiring antidepressant and anti-seizure drugs, fructose and blood pH—in undiluted plasma. This hierarchical surface chemistry is widely applicable to many analytes and provides a generalized platform for SERS-based biosensing in complex real-world media.

Date: 2016
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DOI: 10.1038/ncomms13437

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