Autophagy controls centrosome number by degrading Cep63

Yuichiro Watanabe, Shinya Honda, Akimitsu Konishi, Satoko Arakawa, Michiko Murohashi, Hirofumi Yamaguchi, Satoru Torii, Minoru Tanabe, Shinji Tanaka, Eiji Warabi and Shigeomi Shimizu ()
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Yuichiro Watanabe: Medical Research Institute, Tokyo Medical and Dental University (TMDU)
Shinya Honda: Medical Research Institute, Tokyo Medical and Dental University (TMDU)
Akimitsu Konishi: Medical Research Institute, Tokyo Medical and Dental University (TMDU)
Satoko Arakawa: Medical Research Institute, Tokyo Medical and Dental University (TMDU)
Michiko Murohashi: Medical Research Institute, Tokyo Medical and Dental University (TMDU)
Hirofumi Yamaguchi: Medical Research Institute, Tokyo Medical and Dental University (TMDU)
Satoru Torii: Medical Research Institute, Tokyo Medical and Dental University (TMDU)
Minoru Tanabe: Tokyo Medical and Dental University
Shinji Tanaka: Graduate School of Medicine, Tokyo Medical and Dental University
Eiji Warabi: Faculty of Medicine, University of Tsukuba
Shigeomi Shimizu: Medical Research Institute, Tokyo Medical and Dental University (TMDU)

Nature Communications, 2016, vol. 7, issue 1, 1-12

Abstract: Abstract Centrosome number is associated with the chromosome segregation and genomic stability. The ubiquitin–proteasome system is considered to be the main regulator of centrosome number. However, here we show that autophagy also regulates the number of centrosomes. Autophagy-deficient cells carry extra centrosomes. The autophagic regulation of centrosome number is dependent on a centrosomal protein of 63 (Cep63) given that cells lacking autophagy contain multiple Cep63 dots that are engulfed and digested by autophagy in wild-type cells, and that the upregulation of Cep63 increases centrosome number. Cep63 is recruited to autophagosomes via interaction with p62, a molecule crucial for selective autophagy. In vivo, hematopoietic cells from autophagy-deficient and p62−/− mice also contained multiple centrosomes. These results indicate that autophagy controls centrosome number by degrading Cep63.

Date: 2016
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DOI: 10.1038/ncomms13508

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