Tectal-derived interneurons contribute to phasic and tonic inhibition in the visual thalamus

Polona Jager, Zhiwen Ye, Xiao Yu, Laskaro Zagoraiou, Hong-Ting Prekop, Juha Partanen, Thomas M. Jessell, William Wisden, Stephen G. Brickley () and Alessio Delogu ()
Additional contact information
Polona Jager: Institute of Psychiatry, Psychology and Neuroscience, King’s College London
Zhiwen Ye: Imperial College London
Xiao Yu: Imperial College London
Laskaro Zagoraiou: Biomedical Research Foundation Academy of Athens
Hong-Ting Prekop: Institute of Psychiatry, Psychology and Neuroscience, King’s College London
Juha Partanen: University of Helsinki
Thomas M. Jessell: Howard Hughes Medical Institute, Columbia University
William Wisden: Imperial College London
Stephen G. Brickley: Imperial College London
Alessio Delogu: Institute of Psychiatry, Psychology and Neuroscience, King’s College London

Nature Communications, 2016, vol. 7, issue 1, 1-14

Abstract: Abstract The release of GABA from local interneurons in the dorsal lateral geniculate nucleus (dLGN-INs) provides inhibitory control during visual processing within the thalamus. It is commonly assumed that this important class of interneurons originates from within the thalamic complex, but we now show that during early postnatal development Sox14/Otx2-expressing precursor cells migrate from the dorsal midbrain to generate dLGN-INs. The unexpected extra-diencephalic origin of dLGN-INs sets them apart from GABAergic neurons of the reticular thalamic nucleus. Using optogenetics we show that at increased firing rates tectal-derived dLGN-INs generate a powerful form of tonic inhibition that regulates the gain of thalamic relay neurons through recruitment of extrasynaptic high-affinity GABAA receptors. Therefore, by revising the conventional view of thalamic interneuron ontogeny we demonstrate how a previously unappreciated mesencephalic population controls thalamic relay neuron excitability.

Date: 2016
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/ncomms13579 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13579

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms13579

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().