Blood flow controls bone vascular function and osteogenesis

Saravana K. Ramasamy (), Anjali P. Kusumbe, Maria Schiller, Dagmar Zeuschner, M. Gabriele Bixel, Carlo Milia, Jaba Gamrekelashvili, Anne Limbourg, Alexander Medvinsky, Massimo M. Santoro, Florian P. Limbourg and Ralf H. Adams ()
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Saravana K. Ramasamy: Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine and University of Münster
Anjali P. Kusumbe: Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine and University of Münster
Maria Schiller: Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine and University of Münster
Dagmar Zeuschner: Electron Microscopy Unit, Max-Planck-Institute for Molecular Biomedicine
M. Gabriele Bixel: Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine and University of Münster
Carlo Milia: VIB Vesalius Research Center, KU Leuven
Jaba Gamrekelashvili: Hannover Medical School
Anne Limbourg: Hannover Medical School
Alexander Medvinsky: Research group Ontogeny of Haematopoietic Stem Cells, MRC Centre for Regenerative Medicine, University of Edinburgh
Massimo M. Santoro: VIB Vesalius Research Center, KU Leuven
Florian P. Limbourg: Hannover Medical School
Ralf H. Adams: Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine and University of Münster

Nature Communications, 2016, vol. 7, issue 1, 1-13

Abstract: Abstract While blood vessels play important roles in bone homeostasis and repair, fundamental aspects of vascular function in the skeletal system remain poorly understood. Here we show that the long bone vasculature generates a peculiar flow pattern, which is important for proper angiogenesis. Intravital imaging reveals that vessel growth in murine long bone involves the extension and anastomotic fusion of endothelial buds. Impaired blood flow leads to defective angiogenesis and osteogenesis, and downregulation of Notch signalling in endothelial cells. In aged mice, skeletal blood flow and endothelial Notch activity are also reduced leading to decreased angiogenesis and osteogenesis, which is reverted by genetic reactivation of Notch. Blood flow and angiogenesis in aged mice are also enhanced on administration of bisphosphonate, a class of drugs frequently used for the treatment of osteoporosis. We propose that blood flow and endothelial Notch signalling are key factors controlling ageing processes in the skeletal system.

Date: 2016
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DOI: 10.1038/ncomms13601

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