Coding and decoding libraries of sequence-defined functional copolymers synthesized via photoligation

Nicolas Zydziak, Waldemar Konrad, Florian Feist, Sergii Afonin, Steffen Weidner and Christopher Barner-Kowollik ()
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Nicolas Zydziak: Soft Matter Synthesis Laboratory, Institut für Biologische Grenzflächen, Karlsruhe Institute of Technology (KIT)
Waldemar Konrad: Soft Matter Synthesis Laboratory, Institut für Biologische Grenzflächen, Karlsruhe Institute of Technology (KIT)
Florian Feist: Soft Matter Synthesis Laboratory, Institut für Biologische Grenzflächen, Karlsruhe Institute of Technology (KIT)
Sergii Afonin: Institut für Biologische Grenzflächen, Karlsruhe Institute of Technology (KIT)
Steffen Weidner: BAM-Federal Institute for Materials Research and Testing
Christopher Barner-Kowollik: Soft Matter Synthesis Laboratory, Institut für Biologische Grenzflächen, Karlsruhe Institute of Technology (KIT)

Nature Communications, 2016, vol. 7, issue 1, 1-13

Abstract: Abstract Designing artificial macromolecules with absolute sequence order represents a considerable challenge. Here we report an advanced light-induced avenue to monodisperse sequence-defined functional linear macromolecules up to decamers via a unique photochemical approach. The versatility of the synthetic strategy—combining sequential and modular concepts—enables the synthesis of perfect macromolecules varying in chemical constitution and topology. Specific functions are placed at arbitrary positions along the chain via the successive addition of monomer units and blocks, leading to a library of functional homopolymers, alternating copolymers and block copolymers. The in-depth characterization of each sequence-defined chain confirms the precision nature of the macromolecules. Decoding of the functional information contained in the molecular structure is achieved via tandem mass spectrometry without recourse to their synthetic history, showing that the sequence information can be read. We submit that the presented photochemical strategy is a viable and advanced concept for coding individual monomer units along a macromolecular chain.

Date: 2016
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DOI: 10.1038/ncomms13672

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