Heritability of the shape of subcortical brain structures in the general population

Gennady V. Roshchupkin, Boris A. Gutman, Meike W. Vernooij, Neda Jahanshad, Nicholas G. Martin, Albert Hofman, Katie L. McMahon, Sven J. van der Lee, Cornelia M. van Duijn, Greig I. de Zubicaray, André G. Uitterlinden, Margaret J. Wright, Wiro J. Niessen, Paul M. Thompson, M. Arfan Ikram () and Hieab H. H. Adams
Additional contact information
Gennady V. Roshchupkin: Erasmus MC
Boris A. Gutman: Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey
Meike W. Vernooij: Erasmus MC
Neda Jahanshad: Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey
Nicholas G. Martin: QIMR Berghofer Medical Research Institute
Albert Hofman: Erasmus MC
Katie L. McMahon: Centre for Advanced Imaging, The University of Queensland
Sven J. van der Lee: Erasmus MC
Cornelia M. van Duijn: Erasmus MC
Greig I. de Zubicaray: Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology
André G. Uitterlinden: Erasmus MC
Margaret J. Wright: Centre for Advanced Imaging, The University of Queensland
Wiro J. Niessen: Erasmus MC
Paul M. Thompson: Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of the University of Southern California, Marina del Rey
M. Arfan Ikram: Erasmus MC
Hieab H. H. Adams: Erasmus MC

Nature Communications, 2016, vol. 7, issue 1, 1-8

Abstract: Abstract The volumes of subcortical brain structures are highly heritable, but genetic underpinnings of their shape remain relatively obscure. Here we determine the relative contribution of genetic factors to individual variation in the shape of seven bilateral subcortical structures: the nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen and thalamus. In 3,686 unrelated individuals aged between 45 and 98 years, brain magnetic resonance imaging and genotyping was performed. The maximal heritability of shape varies from 32.7 to 53.3% across the subcortical structures. Genetic contributions to shape extend beyond influences on intracranial volume and the gross volume of the respective structure. The regional variance in heritability was related to the reliability of the measurements, but could not be accounted for by technical factors only. These findings could be replicated in an independent sample of 1,040 twins. Differences in genetic contributions within a single region reveal the value of refined brain maps to appreciate the genetic complexity of brain structures.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13738

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DOI: 10.1038/ncomms13738

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