A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy

Zhenzhen Wang, Yonghu Sun, Xi’an Fu, Gongqi Yu, Chuan Wang, Fangfang Bao, Zhenhua Yue, Jianke Li, Lele Sun, Astrid Irwanto, Yongxiang Yu, Mingfei Chen, Zihao Mi, Honglei Wang, Pengcheng Huai, Yi Li, Tiantian Du, Wenjun Yu, Yang Xia, Hailu Xiao, Jiabao You, Jinghui Li, Qing Yang, Na Wang, Panpan Shang, Guiye Niu, Xiaojun Chi, Xiuhuan Wang, Jing Cao, Xiujun Cheng, Hong Liu (), Jianjun Liu and Furen Zhang ()
Additional contact information
Zhenzhen Wang: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Yonghu Sun: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Xi’an Fu: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Gongqi Yu: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Chuan Wang: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Fangfang Bao: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Zhenhua Yue: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Jianke Li: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Lele Sun: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Astrid Irwanto: Human Genetics, Genome Institute of Singapore
Yongxiang Yu: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Mingfei Chen: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Zihao Mi: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Honglei Wang: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Pengcheng Huai: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Yi Li: Human Genetics, Genome Institute of Singapore
Tiantian Du: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Wenjun Yu: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Yang Xia: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Hailu Xiao: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Jiabao You: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Jinghui Li: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Qing Yang: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Na Wang: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Panpan Shang: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Guiye Niu: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Xiaojun Chi: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Xiuhuan Wang: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Jing Cao: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Xiujun Cheng: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Hong Liu: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences
Jianjun Liu: Human Genetics, Genome Institute of Singapore
Furen Zhang: Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences

Nature Communications, 2016, vol. 7, issue 1, 1-8

Abstract: Abstract Leprosy, a chronic infectious disease, results from the uncultivable pathogen Mycobacterium leprae (M. leprae), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associated with leprosy at the genome-wide significant level. However as a complex disease, only a small proportion of leprosy risk could be explained by those gene/loci. To further identify more susceptibility gene/loci, we hereby performed a three-stage GWAS comprising 8,156 leprosy patients and 15,610 controls of Chinese ancestry. Four novel loci were identified including rs6807915 on 3p25.2 (P=1.94 × 10−8, OR=0.89), rs4720118 on 7p14.3 (P=3.85 × 10−10, OR=1.16), rs55894533 on 8p23.1 (P=5.07 × 10−11, OR=1.15) and rs10100465 on 8q24.11 (P=2.85 × 10−11, OR=0.85). Altogether, these findings have provided new insight and significantly expanded our understanding of the genetic basis of leprosy.

Date: 2016
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DOI: 10.1038/ncomms13760

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