ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversion

Wei-Guang Li, Ming-Gang Liu, Shining Deng, Yan-Mei Liu, Lin Shang, Jing Ding, Tsan-Ting Hsu, Qin Jiang, Ying Li, Fei Li (), Michael Xi Zhu () and Tian-Le Xu ()
Additional contact information
Wei-Guang Li: Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine
Ming-Gang Liu: Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine
Shining Deng: Shanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Ministry of Education–Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine
Yan-Mei Liu: Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine
Lin Shang: Shanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Ministry of Education–Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine
Jing Ding: Shanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Ministry of Education–Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine
Tsan-Ting Hsu: Institute of Neuroscience, National Yang-Ming University
Qin Jiang: Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine
Ying Li: Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine
Fei Li: Shanghai Institute of Pediatric Translational Medicine, Shanghai Children’s Medical Center, Ministry of Education–Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University School of Medicine
Michael Xi Zhu: The University of Texas Health Science Center at Houston
Tian-Le Xu: Discipline of Neuroscience, Histology and Embryology, and Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine

Nature Communications, 2016, vol. 7, issue 1, 1-15

Abstract: Abstract Acid-sensing ion channel 1a (ASIC1a) has been shown to play important roles in synaptic plasticity, learning and memory. Here we identify a crucial role for ASIC1a in long-term depression (LTD) at mouse insular synapses. Genetic ablation and pharmacological inhibition of ASIC1a reduced the induction probability of LTD without affecting that of long-term potentiation in the insular cortex. The disruption of ASIC1a also attenuated the extinction of established taste aversion memory without altering the initial associative taste learning or its long-term retention. Extinction of taste aversive memory led to the reduced insular synaptic efficacy, which precluded further LTD induction. The impaired LTD and extinction learning in ASIC1a null mice were restored by virus-mediated expression of wild-type ASIC1a, but not its ion-impermeable mutant, in the insular cortices. Our data demonstrate the involvement of an ASIC1a-mediated insular synaptic depression mechanism in extinction learning, which raises the possibility of targeting ASIC1a to manage adaptive behaviours.

Date: 2016
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms13770 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13770

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms13770

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().