Serotonergic neuronal death and concomitant serotonin deficiency curb copulation ability of Drosophila platonic mutants

Yasemin B. Yilmazer, Masayuki Koganezawa, Kosei Sato, Jinhua Xu and Daisuke Yamamoto ()
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Yasemin B. Yilmazer: Tohoku University Graduate School of Life Sciences
Masayuki Koganezawa: Tohoku University Graduate School of Life Sciences
Kosei Sato: Tohoku University Graduate School of Life Sciences
Jinhua Xu: School of Medicine and Key Laboratory of Optoelectronic Chemical Materials and Devices, Ministry of Education, Jianghan University
Daisuke Yamamoto: Tohoku University Graduate School of Life Sciences

Nature Communications, 2016, vol. 7, issue 1, 1-9

Abstract: Abstract Drosophila platonic (plt) males court females, but fail to copulate. Here we show that plt is an allele of scribbler (sbb), a BMP signalling component. sbb knockdown in larvae leads to the loss of approximately eight serotonergic neurons, which express the sex-determinant protein Doublesex (Dsx). Genetic deprivation of serotonin (5-HT) from dsx-expressing neurons results in copulation defects. Thus, sbb+ is developmentally required for the survival of a specific subset of dsx-expressing neurons, which support the normal execution of copulation in adults by providing 5-HT. Our study highlights the conserved involvement of serotonergic neurons in the control of copulatory mechanisms and the key role of BMP signalling in the formation of a sex-specific circuitry.

Date: 2016
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DOI: 10.1038/ncomms13792

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