Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D

E. Nicholas Petersen, Hae-Won Chung, Arman Nayebosadri and Scott B. Hansen ()
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E. Nicholas Petersen: The Scripps Research Institute
Hae-Won Chung: The Scripps Research Institute
Arman Nayebosadri: The Scripps Research Institute
Scott B. Hansen: The Scripps Research Institute

Nature Communications, 2016, vol. 7, issue 1, 1-8

Abstract: Abstract The sensing of physical force, mechanosensation, underlies two of five human senses—touch and hearing. How transduction of force in a membrane occurs remains unclear. We asked if a biological membrane could employ kinetic energy to transduce a signal absent tension. Here we show that lipid rafts are dynamic compartments that inactivate the signalling enzyme phospholipase D2 (PLD2) by sequestering the enzyme from its substrate. Mechanical disruption of the lipid rafts activates PLD2 by mixing the enzyme with its substrate to produce the signalling lipid phosphatidic acid (PA). We calculate a latency time of

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms13873

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DOI: 10.1038/ncomms13873

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