Therapeutic microparticles functionalized with biomimetic cardiac stem cell membranes and secretome

Junnan Tang, Deliang Shen, Thomas George Caranasos, Zegen Wang, Adam C. Vandergriff, Tyler A. Allen, Michael Taylor Hensley, Phuong-Uyen Dinh, Jhon Cores, Tao-Sheng Li, Jinying Zhang (), Quancheng Kan () and Ke Cheng ()
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Junnan Tang: The First Affiliated Hospital of Zhengzhou University
Deliang Shen: The First Affiliated Hospital of Zhengzhou University
Thomas George Caranasos: University of North Carolina at Chapel Hill
Zegen Wang: The Cyrus Tang Hematology Center, Soochow University
Adam C. Vandergriff: North Carolina State University
Tyler A. Allen: North Carolina State University
Michael Taylor Hensley: North Carolina State University
Phuong-Uyen Dinh: North Carolina State University
Jhon Cores: North Carolina State University
Tao-Sheng Li: Atomic Bomb Disease Institute, Nagasaki University
Jinying Zhang: The First Affiliated Hospital of Zhengzhou University
Quancheng Kan: The First Affiliated Hospital of Zhengzhou University
Ke Cheng: North Carolina State University

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract Stem cell therapy represents a promising strategy in regenerative medicine. However, cells need to be carefully preserved and processed before usage. In addition, cell transplantation carries immunogenicity and/or tumourigenicity risks. Mounting lines of evidence indicate that stem cells exert their beneficial effects mainly through secretion (of regenerative factors) and membrane-based cell–cell interaction with the injured cells. Here, we fabricate a synthetic cell-mimicking microparticle (CMMP) that recapitulates stem cell functions in tissue repair. CMMPs carry similar secreted proteins and membranes as genuine cardiac stem cells do. In a mouse model of myocardial infarction, injection of CMMPs leads to the preservation of viable myocardium and augmentation of cardiac functions similar to cardiac stem cell therapy. CMMPs (derived from human cells) do not stimulate T-cell infiltration in immuno-competent mice. In conclusion, CMMPs act as ‘synthetic stem cells’ which mimic the paracrine and biointerfacing activities of natural stem cells in therapeutic cardiac regeneration.

Date: 2017
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DOI: 10.1038/ncomms13724

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