JAK/STAT controls organ size and fate specification by regulating morphogen production and signalling

Carles Recasens-Alvarez, Ana Ferreira and Marco Milán ()
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Carles Recasens-Alvarez: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Ana Ferreira: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology
Marco Milán: Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract A stable pool of morphogen-producing cells is critical for the development of any organ or tissue. Here we present evidence that JAK/STAT signalling in the Drosophila wing promotes the cycling and survival of Hedgehog-producing cells, thereby allowing the stable localization of the nearby BMP/Dpp-organizing centre in the developing wing appendage. We identify the inhibitor of apoptosis dIAP1 and Cyclin A as two critical genes regulated by JAK/STAT and contributing to the growth of the Hedgehog-expressing cell population. We also unravel an early role of JAK/STAT in guaranteeing Wingless-mediated appendage specification, and a later one in restricting the Dpp-organizing activity to the appendage itself. These results unveil a fundamental role of the conserved JAK/STAT pathway in limb specification and growth by regulating morphogen production and signalling, and a function of pro-survival cues and mitogenic signals in the regulation of the pool of morphogen-producing cells in a developing organ.

Date: 2017
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DOI: 10.1038/ncomms13815

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