Nonlinear detection of secondary isotopic chemical shifts in NMR through spin noise

Maria Theresia Pöschko, Victor V. Rodin, Judith Schlagnitweit, Norbert Müller and Hervé Desvaux ()
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Maria Theresia Pöschko: Institute of Organic Chemistry, Johannes Kepler University Linz
Victor V. Rodin: Institute of Organic Chemistry, Johannes Kepler University Linz
Judith Schlagnitweit: Institute of Organic Chemistry, Johannes Kepler University Linz
Norbert Müller: Institute of Organic Chemistry, Johannes Kepler University Linz
Hervé Desvaux: NIMBE, CEA, CNRS, Université Paris-Saclay, CEA/Saclay

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract The detection of minor species in the presence of large amounts of similar main components remains a key challenge in analytical chemistry, for instance, to obtain isotopic fingerprints. As an alternative to the classical NMR scheme based on coherent excitation and detection, here we introduce an approach based on spin-noise detection. Chemical shifts and transverse relaxation rates are determined using only the detection circuit. Thanks to a nonlinear effect in mixtures with small chemical shift dispersion, small signals on top of a larger one can be observed with increased sensitivity as bumps on a dip; the latter being the signature of the main magnetization. Experimental observations are underpinned by an analytical theory: the coupling between the magnetization and the coil provides an amplified detection capability of both small static magnetic field inhomogeneities and small NMR signals. This is illustrated by two-bond 12C/13C isotopic measurements.

Date: 2017
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DOI: 10.1038/ncomms13914

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