The immunoreceptor NKG2D promotes tumour growth in a model of hepatocellular carcinoma

Sam Sheppard, Joana Guedes, Anna Mroz, Anastasia-Maria Zavitsanou, Hiromi Kudo, Stephen M. Rothery, Panagiotis Angelopoulos, Robert Goldin and Nadia Guerra ()
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Sam Sheppard: Imperial College London
Joana Guedes: Imperial College London
Anna Mroz: Imperial College London
Anastasia-Maria Zavitsanou: Imperial College London
Hiromi Kudo: Imperial College London
Stephen M. Rothery: Facility for Imaging by Light Microscopy, Imperial College London
Panagiotis Angelopoulos: National Technical University of Athens
Robert Goldin: Imperial College London
Nadia Guerra: Imperial College London

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Inflammation is recognized as one of the drivers of cancer. Yet, the individual immune components that possess pro- and anti-tumorigenic functions in individual cancers remain largely unknown. NKG2D is a potent activating immunoreceptor that has emerged as an important player in inflammatory disorders besides its well-established function as tumour suppressor. Here, we provide genetic evidence of an unexpected tumour-promoting effect of NKG2D in a model of inflammation-driven liver cancer. Compared to NKG2D-deficient mice, NKG2D-sufficient mice display accelerated tumour growth associated with, an increased recruitment of memory CD8+T cells to the liver and exacerbated pro-inflammatory milieu. In addition, we show that NKG2D contributes to liver damage and consequent hepatocyte proliferation known to favour tumorigenesis. Thus, the NKG2D/NKG2D-ligand pathway provides an additional mechanism linking chronic inflammation to tumour development in hepatocellular carcinoma. Our findings expose the need to selectively target the types of cancer that could benefit from NKG2D-based immunotherapy.

Date: 2017
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DOI: 10.1038/ncomms13930

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