Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD

Xiaohua Yu, Yong Zhang (), Tingting Li, Zhao Ma, Haixue Jia, Qian Chen, Yixia Zhao, Lili Zhai, Ran Zhong, Changyin Li, Xiaoting Zou, Jiao Meng, Antony K. Chen, Pier Lorenzo Puri, Meihong Chen and Dahai Zhu ()
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Xiaohua Yu: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
Yong Zhang: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
Tingting Li: School of Basic Medical Sciences, Peking University Health Science Center
Zhao Ma: College of Engineering, Peking University
Haixue Jia: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
Qian Chen: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
Yixia Zhao: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
Lili Zhai: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
Ran Zhong: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
Changyin Li: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
Xiaoting Zou: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
Jiao Meng: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
Antony K. Chen: College of Engineering, Peking University
Pier Lorenzo Puri: Developmental Aging and Regeneration Program, Sanford-Burnham-Prebys Medical Discovery Institute
Meihong Chen: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College
Dahai Zhu: The State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Long non-coding RNAs (lncRNAs) are important regulators of diverse biological processes. Here we report on functional identification and characterization of a novel long intergenic non-coding RNA with MyoD-regulated and skeletal muscle-restricted expression that promotes the activation of the myogenic program, and is therefore termed Linc-RAM (Linc-RNA Activator of Myogenesis). Linc-RAM is transcribed from an intergenic region of myogenic cells and its expression is upregulated during myogenesis. Notably, in vivo functional studies show that Linc-RAM knockout mice display impaired muscle regeneration due to the differentiation defect of satellite cells. Mechanistically, Linc-RAM regulates expression of myogenic genes by directly binding MyoD, which in turn promotes the assembly of the MyoD–Baf60c–Brg1 complex on the regulatory elements of target genes. Collectively, our findings reveal the functional role and molecular mechanism of a lineage-specific Linc-RAM as a regulatory lncRNA required for tissues-specific chromatin remodelling and gene expression.

Date: 2017
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DOI: 10.1038/ncomms14016

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