Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

Xusheng Wang, Haiyan Chen, Ruiyun Tian, Yiling Zhang, Marina S. Drutskaya, Chengmei Wang, Jianfeng Ge, Zhimeng Fan, Deqiang Kong, Xiaoxiao Wang, Ting Cai, Ying Zhou, Jingwen Wang, Jinmei Wang, Shan Wang, Zhihai Qin, Huanhuan Jia, Yue Wu, Jia Liu, Sergei A. Nedospasov, Edward E. Tredget, Mei Lin, Jianjun Liu, Yuyang Jiang () and Yaojiong Wu ()
Additional contact information
Xusheng Wang: School of Life Sciences, Tsinghua University
Haiyan Chen: The Shenzhen Key Laboratory of Health Sciences and Technology
Ruiyun Tian: The Shenzhen Key Laboratory of Health Sciences and Technology
Yiling Zhang: The General Hospital of Chinese People's Liberation Army
Marina S. Drutskaya: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Chengmei Wang: School of Life Sciences, Tsinghua University
Jianfeng Ge: School of Life Sciences, Tsinghua University
Zhimeng Fan: School of Life Sciences, Tsinghua University
Deqiang Kong: School of Life Sciences, Tsinghua University
Xiaoxiao Wang: School of Life Sciences, Tsinghua University
Ting Cai: School of Life Sciences, Tsinghua University
Ying Zhou: School of Life Sciences, Tsinghua University
Jingwen Wang: School of Life Sciences, Tsinghua University
Jinmei Wang: School of Life Sciences, Tsinghua University
Shan Wang: School of Life Sciences, Tsinghua University
Zhihai Qin: Institute of Biophysics, Chinese Academy of Sciences
Huanhuan Jia: Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals
Yue Wu: Guangdong Laboratory Animals Monitoring Institute, Guangdong Provincial Key Laboratory of Laboratory Animals
Jia Liu: College of Life Sciences, Northeast Forestry University
Sergei A. Nedospasov: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Edward E. Tredget: Wound Healing Research Group, University of Alberta
Mei Lin: The Shenzhen Key Laboratory of Health Sciences and Technology
Jianjun Liu: Medical Key Laboratory of Health Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention
Yuyang Jiang: State Key Laboratory Breeding Base-Shenzhen Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University
Yaojiong Wu: The Shenzhen Key Laboratory of Health Sciences and Technology

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract Skin stem cells can regenerate epidermal appendages; however, hair follicles (HF) lost as a result of injury are barely regenerated. Here we show that macrophages in wounds activate HF stem cells, leading to telogen–anagen transition (TAT) around the wound and de novo HF regeneration, mostly through TNF signalling. Both TNF knockout and overexpression attenuate HF neogenesis in wounds, suggesting dose-dependent induction of HF neogenesis by TNF, which is consistent with TNF-induced AKT signalling in epidermal stem cells in vitro. TNF-induced β-catenin accumulation is dependent on AKT but not Wnt signalling. Inhibition of PI3K/AKT blocks depilation-induced HF TAT. Notably, Pten loss in Lgr5+ HF stem cells results in HF TAT independent of injury and promotes HF neogenesis after wounding. Thus, our results suggest that macrophage-TNF-induced AKT/β-catenin signalling in Lgr5+ HF stem cells has a crucial role in promoting HF cycling and neogenesis after wounding.

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms14091 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14091

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms14091

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().