SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers

Vural Tagal, Shuguang Wei, Wei Zhang, Rolf A. Brekken, Bruce A. Posner, Michael Peyton, Luc Girard, TaeHyun Hwang, David A. Wheeler, John D. Minna, Michael A. White, Adi F. Gazdar and Michael G. Roth ()
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Vural Tagal: UT Southwestern
Shuguang Wei: UT Southwestern
Wei Zhang: UT Southwestern
Rolf A. Brekken: Hamon Center for Therapeutic Oncology Research, UT Southwestern
Bruce A. Posner: UT Southwestern
Michael Peyton: Hamon Center for Therapeutic Oncology Research, UT Southwestern
Luc Girard: Hamon Center for Therapeutic Oncology Research, UT Southwestern
TaeHyun Hwang: UT Southwestern
David A. Wheeler: Baylor College of Medicine
John D. Minna: Hamon Center for Therapeutic Oncology Research, UT Southwestern
Michael A. White: Harold Simmons Comprehensive Cancer Center, UT Southwestern
Adi F. Gazdar: UT Southwestern
Michael G. Roth: UT Southwestern

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Mutations in the SMARCA4/BRG1 gene resulting in complete loss of its protein (BRG1) occur frequently in non-small cell lung cancer (NSCLC) cells. Currently, no single therapeutic agent has been identified as synthetically lethal with SMARCA4/BRG1 loss. We identify AURKA activity as essential in NSCLC cells lacking SMARCA4/BRG1. In these cells, RNAi-mediated depletion or chemical inhibition of AURKA induces apoptosis and cell death in vitro and in xenograft mouse models. Disc large homologue-associated protein 5 (HURP/DLGAP5), required for AURKA-dependent, centrosome-independent mitotic spindle assembly is essential for the survival and proliferation of SMARCA4/BRG1 mutant but not of SMARCA4/BRG1 wild-type cells. AURKA inhibitors may provide a therapeutic strategy for biomarker-driven clinical studies to treat the NSCLCs harbouring SMARCA4/BRG1-inactivating mutations.

Date: 2017
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DOI: 10.1038/ncomms14098

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