Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents
Christian Büchel,
Jan Peters,
Tobias Banaschewski,
Arun L. W. Bokde,
Uli Bromberg,
Patricia J. Conrod,
Herta Flor,
Dimitri Papadopoulos,
Hugh Garavan,
Penny Gowland,
Andreas Heinz,
Henrik Walter,
Bernd Ittermann,
Karl Mann,
Jean-Luc Martinot,
Marie-Laure Paillère-Martinot,
Frauke Nees,
Tomas Paus,
Zdenka Pausova,
Luise Poustka,
Marcella Rietschel,
Trevor W. Robbins,
Michael N. Smolka,
Juergen Gallinat,
Gunter Schumann and
Brian Knutson
Additional contact information
Christian Büchel: Universitätsklinikum Hamburg Eppendorf
Jan Peters: Universitätsklinikum Hamburg Eppendorf
Tobias Banaschewski: Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Arun L. W. Bokde: Institute of Neuroscience and Discipline of Psychiatry, School of Medicine, Trinity College Dublin
Uli Bromberg: Universitätsklinikum Hamburg Eppendorf
Patricia J. Conrod: Institute of Psychiatry, King’s College London
Herta Flor: Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Dimitri Papadopoulos: Commissariat à l’Energie Atomique et aux Energies Alternatives
Hugh Garavan: Institute of Neuroscience, Trinity College Dublin
Penny Gowland: School of Physics and Astronomy, University of Nottingham
Andreas Heinz: Campus Charité Mitte, Charité—Universitätsmedizin Berlin
Henrik Walter: Campus Charité Mitte, Charité—Universitätsmedizin Berlin
Bernd Ittermann: Physikalisch-Technische Bundesanstalt (PTB)
Karl Mann: Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Jean-Luc Martinot: Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 ‘Imaging & Psychiatry’, University Paris-Sud
Marie-Laure Paillère-Martinot: Institut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 ‘Imaging & Psychiatry’, University Paris-Sud
Frauke Nees: Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Tomas Paus: McGill University and Genome Quebec Innovation Centre
Zdenka Pausova: The Hospital for Sick Children, University of Toronto
Luise Poustka: Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Marcella Rietschel: Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
Trevor W. Robbins: Behavioural and Clinical Neurosciences Institute, University of Cambridge
Michael N. Smolka: and Neuroimaging Center, Technische Universität Dresden
Juergen Gallinat: Campus Charité Mitte, Charité—Universitätsmedizin Berlin
Gunter Schumann: Institute of Psychiatry, King’s College London
Nature Communications, 2017, vol. 8, issue 1, 1-11
Abstract:
Abstract Novelty-seeking tendencies in adolescents may promote innovation as well as problematic impulsive behaviour, including drug abuse. Previous research has not clarified whether neural hyper- or hypo-responsiveness to anticipated rewards promotes vulnerability in these individuals. Here we use a longitudinal design to track 144 novelty-seeking adolescents at age 14 and 16 to determine whether neural activity in response to anticipated rewards predicts problematic drug use. We find that diminished BOLD activity in mesolimbic (ventral striatal and midbrain) and prefrontal cortical (dorsolateral prefrontal cortex) regions during reward anticipation at age 14 predicts problematic drug use at age 16. Lower psychometric conscientiousness and steeper discounting of future rewards at age 14 also predicts problematic drug use at age 16, but the neural responses independently predict more variance than psychometric measures. Together, these findings suggest that diminished neural responses to anticipated rewards in novelty-seeking adolescents may increase vulnerability to future problematic drug use.
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14140
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DOI: 10.1038/ncomms14140
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