Dietary fatty acid metabolism of brown adipose tissue in cold-acclimated men

Denis P. Blondin, Hans C. Tingelstad, Christophe Noll, Frédérique Frisch, Serge Phoenix, Brigitte Guérin, Éric E Turcotte, Denis Richard, François Haman () and André C. Carpentier ()
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Denis P. Blondin: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke
Hans C. Tingelstad: Faculty of Health Sciences, University of Ottawa
Christophe Noll: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke
Frédérique Frisch: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke
Serge Phoenix: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke
Brigitte Guérin: Centre d'imagerie Moléculaire de Sherbrooke, Université de Sherbrooke
Éric E Turcotte: Centre d'imagerie Moléculaire de Sherbrooke, Université de Sherbrooke
Denis Richard: Centre de Recherche de l’Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval
François Haman: Faculty of Health Sciences, University of Ottawa
André C. Carpentier: Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke

Nature Communications, 2017, vol. 8, issue 1, 1-9

Abstract: Abstract In rodents, brown adipose tissue (BAT) plays an important role in producing heat to defend against the cold and can metabolize large amounts of dietary fatty acids (DFA). The role of BAT in DFA metabolism in humans is unknown. Here we show that mild cold stimulation (18 °C) results in a significantly greater fractional DFA extraction by BAT relative to skeletal muscle and white adipose tissue in non-cold-acclimated men given a standard liquid meal containing the long-chain fatty acid PET tracer, 14(R,S)-[18F]-fluoro-6-thia-heptadecanoic acid (18FTHA). However, the net contribution of BAT to systemic DFA clearance is comparatively small. Despite a 4-week cold acclimation increasing BAT oxidative metabolism 2.6-fold, BAT DFA uptake does not increase further. These findings show that cold-stimulated BAT can contribute to the clearance of DFA from circulation but its contribution is not as significant as the heart, liver, skeletal muscles or white adipose tissues.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14146

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DOI: 10.1038/ncomms14146

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