Drosophila FIT is a protein-specific satiety hormone essential for feeding control

Jinghan Sun, Chang Liu, Xiaobing Bai, Xiaoting Li, Jingyun Li, Zhiping Zhang, Yunpeng Zhang, Jing Guo and Yan Li ()
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Jinghan Sun: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
Chang Liu: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
Xiaobing Bai: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
Xiaoting Li: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
Jingyun Li: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
Zhiping Zhang: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
Yunpeng Zhang: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
Jing Guo: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences
Yan Li: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Protein homeostasis is critical for health and lifespan of animals. However, the mechanisms for controlling protein feeding remain poorly understood. Here we report that in Drosophila, protein intake-induced feeding inhibition (PIFI) is specific to protein-containing food, and this effect is mediated by a fat body (FB) peptide named female-specific independent of transformer (FIT). Upon consumption of protein food, FIT expression is greatly elevated. Secreted FIT peptide in the fly haemolymph conveys this metabolic message to the brain, thereby promoting the release of Drosophila insulin-like peptide 2 (DILP2) and suppressing further protein intake. Interestingly, Fit is a sexually dimorphic gene, and consequently protein consumption-induced insulin release, as well as protein feeding behaviour, are also dimorphic between sexes. Thus, our findings reveal a protein-specific satiety hormone, providing important insights into the complex regulation of feeding decision, as well as the sexual dimorphism in feeding behaviour.

Date: 2017
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DOI: 10.1038/ncomms14161

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