Clustering of 770,000 genomes reveals post-colonial population structure of North America

Eunjung Han, Peter Carbonetto, Ross E. Curtis, Yong Wang, Julie M. Granka, Jake Byrnes, Keith Noto, Amir R. Kermany, Natalie M. Myres, Mathew J. Barber, Kristin A. Rand, Shiya Song, Theodore Roman, Erin Battat, Eyal Elyashiv, Harendra Guturu, Eurie L. Hong, Kenneth G. Chahine and Catherine A. Ball ()
Additional contact information
Eunjung Han: AncestryDNA
Peter Carbonetto: AncestryDNA
Ross E. Curtis: AncestryDNA
Yong Wang: AncestryDNA
Julie M. Granka: AncestryDNA
Jake Byrnes: AncestryDNA
Keith Noto: AncestryDNA
Amir R. Kermany: AncestryDNA
Natalie M. Myres: AncestryDNA
Mathew J. Barber: AncestryDNA
Kristin A. Rand: AncestryDNA
Shiya Song: University of Michigan
Theodore Roman: School of Computer Science, Carnegie Mellon University
Erin Battat: W.E.B. Du Bois Research Institute, Hutchins Center for African and African American Research, Harvard University
Eyal Elyashiv: AncestryDNA
Harendra Guturu: AncestryDNA
Eurie L. Hong: AncestryDNA
Kenneth G. Chahine: AncestryDNA
Catherine A. Ball: AncestryDNA

Nature Communications, 2017, vol. 8, issue 1, 1-12

Abstract: Abstract Despite strides in characterizing human history from genetic polymorphism data, progress in identifying genetic signatures of recent demography has been limited. Here we identify very recent fine-scale population structure in North America from a network of over 500 million genetic (identity-by-descent, IBD) connections among 770,000 genotyped individuals of US origin. We detect densely connected clusters within the network and annotate these clusters using a database of over 20 million genealogical records. Recent population patterns captured by IBD clustering include immigrants such as Scandinavians and French Canadians; groups with continental admixture such as Puerto Ricans; settlers such as the Amish and Appalachians who experienced geographic or cultural isolation; and broad historical trends, including reduced north-south gene flow. Our results yield a detailed historical portrait of North America after European settlement and support substantial genetic heterogeneity in the United States beyond that uncovered by previous studies.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14238

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DOI: 10.1038/ncomms14238

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