Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer

Thomas J. Hoffmann, Michael N. Passarelli, Rebecca E. Graff, Nima C. Emami, Lori C. Sakoda, Eric Jorgenson, Laurel A. Habel, Jun Shan, Dilrini K. Ranatunga, Charles P. Quesenberry, Chun R. Chao, Nirupa R. Ghai, David Aaronson, Joseph Presti, Tobias Nordström, Zhaoming Wang, Sonja I. Berndt, Stephen J. Chanock, Jonathan D. Mosley, Robert J. Klein, Mridu Middha, Hans Lilja, Olle Melander, Mark N. Kvale, Pui-Yan Kwok, Catherine Schaefer, Neil Risch, Stephen K. Van Den Eeden () and John S. Witte ()
Additional contact information
Thomas J. Hoffmann: University of California San Francisco
Michael N. Passarelli: University of California San Francisco
Rebecca E. Graff: University of California San Francisco
Nima C. Emami: University of California San Francisco
Lori C. Sakoda: Kaiser Permanente, Northern California
Eric Jorgenson: Kaiser Permanente, Northern California
Laurel A. Habel: Kaiser Permanente, Northern California
Jun Shan: Kaiser Permanente, Northern California
Dilrini K. Ranatunga: Kaiser Permanente, Northern California
Charles P. Quesenberry: Kaiser Permanente, Northern California
Chun R. Chao: Kaiser Permanente Southern California
Nirupa R. Ghai: Kaiser Permanente Southern California
David Aaronson: Kaiser Oakland Medical Center, Northern California
Joseph Presti: Kaiser Oakland Medical Center, Northern California
Tobias Nordström: Karolinska Institutet
Zhaoming Wang: Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
Sonja I. Berndt: Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
Stephen J. Chanock: Laboratory of Translational Genomics, National Cancer Institute, National Institutes of Health
Jonathan D. Mosley: Vanderbilt University
Robert J. Klein: Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
Mridu Middha: Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai
Hans Lilja: Surgery, and Medicine, Memorial Sloan-Kettering Cancer Center
Olle Melander: Lund University
Mark N. Kvale: Institute for Human Genetics, University of California San Francisco
Pui-Yan Kwok: Institute for Human Genetics, University of California San Francisco
Catherine Schaefer: Kaiser Permanente, Northern California
Neil Risch: University of California San Francisco
Stephen K. Van Den Eeden: Kaiser Permanente, Northern California
John S. Witte: University of California San Francisco

Nature Communications, 2017, vol. 8, issue 1, 1-11

Abstract: Abstract Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa—such as genetics—can impact PSA. Here we present findings from a genome-wide association study (GWAS) of PSA in 28,503 Kaiser Permanente whites and 17,428 men from replication cohorts. We detect 40 genome-wide significant (P

Date: 2017
References: Add references at CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/ncomms14248 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_ncomms14248

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/ncomms14248

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().