Natural amines inhibit activation of human plasmacytoid dendritic cells through CXCR4 engagement

Nikaïa Smith, Nicolas Pietrancosta (), Sophia Davidson, Jacques Dutrieux, Lise Chauveau, Pasquale Cutolo, Michel Dy, Daniel Scott-Algara, Bénédicte Manoury, Onofrio Zirafi, Isabelle McCort-Tranchepain, Thierry Durroux, Françoise Bachelerie, Olivier Schwartz, Jan Münch, Andreas Wack, Sébastien Nisole and Jean-Philippe Herbeuval ()
Additional contact information
Nikaïa Smith: CNRS UMR-8601, Université Paris Descartes, CICB
Nicolas Pietrancosta: CNRS UMR-8601, Université Paris Descartes, CICB
Sophia Davidson: Immunoregulation Laboratory, Francis Crick Institute
Jacques Dutrieux: INSERM UMR-S 1124, Université Paris Descartes
Lise Chauveau: Institut Pasteur, Virus & Immunity Unit
Pasquale Cutolo: Inflammation Chimiokines et Immunopathologie, INSERM, Faculté de médecine—Université Paris-Sud, Université Paris-Saclay
Michel Dy: CNRS UMR-8147, Hôpital Necker
Daniel Scott-Algara: Institut Pasteur, Unité de Régulation des Infections Rétrovirales
Bénédicte Manoury: INSERM U1151, CNRS8253, Université Paris Descartes, Hôpital Necker
Onofrio Zirafi: Institute of Molecular Virology, Ulm University Medical Center
Isabelle McCort-Tranchepain: CNRS UMR-8601, Université Paris Descartes, CICB
Thierry Durroux: Institut de Génomique Fonctionnelle, CNRS UMR5203, INSERM U661, Université de Montpellier (IFR3)
Françoise Bachelerie: Inflammation Chimiokines et Immunopathologie, INSERM, Faculté de médecine—Université Paris-Sud, Université Paris-Saclay
Olivier Schwartz: Institut Pasteur, Virus & Immunity Unit
Jan Münch: Institute of Molecular Virology, Ulm University Medical Center
Andreas Wack: Immunoregulation Laboratory, Francis Crick Institute
Sébastien Nisole: INSERM UMR-S 1124, Université Paris Descartes
Jean-Philippe Herbeuval: CNRS UMR-8601, Université Paris Descartes, CICB

Nature Communications, 2017, vol. 8, issue 1, 1-13

Abstract: Abstract Plasmacytoid dendritic cells (pDC) are specialized in secretion of type I interferon in response to pathogens. Here we show that natural monoamines and synthetic amines inhibit pDC activation by RNA viruses. Furthermore, a synthetic analogue of histamine reduces type I interferon production in a mouse model of influenza infection. We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by amines to inhibit pDC. Our study establishes a functional link between natural amines and the innate immune system and identifies CXCR4 as a potential ‘on-off’ switch of pDC activity with therapeutic potential.

Date: 2017
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DOI: 10.1038/ncomms14253

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