MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes

Can Liu (), Ruifang Liu (), Dingxiao Zhang, Qu Deng, Bigang Liu, Hsueh-Ping Chao, Kiera Rycaj, Yoko Takata, Kevin Lin, Yue Lu, Yi Zhong, John Krolewski, Jianjun Shen and Dean G. Tang ()
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Can Liu: University of Texas MD Anderson Cancer Center
Ruifang Liu: University of Texas MD Anderson Cancer Center
Dingxiao Zhang: University of Texas MD Anderson Cancer Center
Qu Deng: University of Texas MD Anderson Cancer Center
Bigang Liu: University of Texas MD Anderson Cancer Center
Hsueh-Ping Chao: University of Texas MD Anderson Cancer Center
Kiera Rycaj: University of Texas MD Anderson Cancer Center
Yoko Takata: University of Texas MD Anderson Cancer Center
Kevin Lin: University of Texas MD Anderson Cancer Center
Yue Lu: University of Texas MD Anderson Cancer Center
Yi Zhong: University of Texas MD Anderson Cancer Center
John Krolewski: Roswell Park Cancer Institute
Jianjun Shen: University of Texas MD Anderson Cancer Center
Dean G. Tang: University of Texas MD Anderson Cancer Center

Nature Communications, 2017, vol. 8, issue 1, 1-14

Abstract: Abstract MicroRNAs play important roles in regulating tumour development, progression and metastasis. Here we show that one of the miR-200 family members, miR-141, is under-expressed in several prostate cancer (PCa) stem/progenitor cell populations in both xenograft and primary patient tumours. Enforced expression of miR-141 in CD44+ and bulk PCa cells inhibits cancer stem cell properties including holoclone and sphere formation, as well as invasion, and suppresses tumour regeneration and metastasis. Moreover, miR-141 expression enforces a strong epithelial phenotype with a partial loss of mesenchymal phenotype. Whole-genome RNA sequencing uncovers novel miR-141-regulated molecular targets in PCa cells including the Rho GTPase family members (for example, CDC42, CDC42EP3, RAC1 and ARPC5) and stem cell molecules CD44 and EZH2, all of which are validated as direct and functionally relevant targets of miR-141. Our results suggest that miR-141 employs multiple mechanisms to obstruct tumour growth and metastasis.

Date: 2017
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DOI: 10.1038/ncomms14270

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